反式-（1R，2R）-二氨基环己烷官能化的介孔有机二氧化硅球体为手性固定相。,Journal of Chromatography A

当前位置： X-MOL 学术 › J. Chromatogr. A › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

反式-（1R，2R）-二氨基环己烷官能化的介孔有机二氧化硅球体为手性固定相。
Journal of Chromatography A ( IF 3.8 ) Pub Date : 2007 May 18 , DOI: 10.1016/j.chroma.2007.03.011
Guiru Zhu , Dongmei Jiang , Qihua Yang , Jie Yang , Can Li

合成了在孔中具有反式（1R，2R）-二氨基环己烷（DACH）的双功能介孔有机硅球，并证明了它们在高效液相色谱（HPLC）中的手性固定相的应用。通过将N- [3-（三乙氧基甲硅烷基）丙基]-反式-（1R，2R）-二氨基环己烷（M（丙基））与1的共缩合制备具有5-7微米窄粒度分布的双功能介孔有机硅球体。在十八烷基三甲基氯化铵（C（18）TACl）为结构导向剂，乙醇为助溶剂的碱性介质中的1,2-双（三甲氧基甲硅烷基）乙烷（BTME）。双功能介孔有机硅的形态对M（丙基）的摩尔分数敏感。在较高的M（丙基）/ BTME摩尔比下，可以在广泛的合成条件下形成具有有序介孔结构的双官能化有机硅球。当M（丙基）/（M（丙基）+ BTME）的摩尔百分比小于20时，几乎观察不到球的形成。材料的结构顺序主要取决于初始溶胶混合物中的碱浓度和M（丙基）/ BTME摩尔比。填充有双功能介孔有机硅胶球的色谱柱比通过常规后合成接枝方法制备的填充DACH-SiO（2）的色谱柱对消旋氨基酸表现出更高的选择性和分辨率。材料的结构顺序主要取决于初始溶胶混合物中的碱浓度和M（丙基）/ BTME摩尔比。填充有双功能介孔有机硅胶球的色谱柱比通过常规后合成接枝方法制备的填充DACH-SiO（2）的色谱柱对消旋氨基酸表现出更高的选择性和分辨率。材料的结构顺序主要取决于初始溶胶混合物中的碱浓度和M（丙基）/ BTME摩尔比。填充有双功能介孔有机硅胶球的色谱柱比通过常规后合成接枝方法制备的填充DACH-SiO（2）的色谱柱对消旋氨基酸表现出更高的选择性和分辨率。

"点击查看英文标题和摘要"

trans-(1R,2R)-Diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase.

The bifunctionalized mesoporous organosilica spheres with trans-(1R,2R)-diaminocyclohexane (DACH) in the pore were synthesized and their application as chiral stationary phase in high-performance liquid chromatography (HPLC) was demonstrated. Bifunctionalized mesoporous organosilica spheres with narrow particle size distribution of 5-7 microm were prepared by the co-condensation of N-[3-(triethoxysilyl)propyl]-trans-(1R,2R)-diaminocyclohexane (M(propyl)) with 1,2-bis(trimethoxysilyl)ethane (BTME) in basic medium using octadecyltrimethylammonium chloride (C(18)TACl) as structural directing agent and ethanol as co-solvent. The morphologies of the bifunctionalized mesoporous organosilicas were sensitive to the molar fraction of M(propyl). At higher M(propyl)/BTME molar ratio, the bifunctionalized organosilica spheres with ordered mesoporous structure can be formed in a wide range of synthetic conditions. When the molar percent of M(propyl)/(M(propyl)+BTME) is less than 20, the formation of spheres could be hardly observed. The structural order of the materials mainly depends on the base concentration and M(propyl)/BTME molar ratio in the initial sol mixture. A column packed with the bifunctionalized mesoporous organosilica spheres exhibits higher selectivity and resolution for racemic amino acids than that packed with DACH-SiO(2) prepared by conventional post-synthesis grafting method.

更新日期：2017-01-31

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>