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Glycan complexity dictates microbial resource allocation in the large intestine.
Nature Communications ( IF 14.7 ) Pub Date : 2015-Jun-26 , DOI: 10.1038/ncomms8481
Artur Rogowski 1 , Jonathon A Briggs 1 , Jennifer C Mortimer 2 , Theodora Tryfona 2 , Nicolas Terrapon 3 , Elisabeth C Lowe 1 , Arnaud Baslé 1 , Carl Morland 1 , Alison M Day 1 , Hongjun Zheng 1 , Theresa E Rogers 4 , Paul Thompson 1 , Alastair R Hawkins 1 , Madhav P Yadav 5 , Bernard Henrissat 6 , Eric C Martens 4 , Paul Dupree 2 , Harry J Gilbert 1 , David N Bolam 1
Affiliation  

The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota.

中文翻译:

聚糖的复杂性决定了大肠中微生物资源的分配。

人类肠道微生物群的结构主要通过复杂膳食碳水化合物的降解来控制,但碳水化合物分解产物在微生物群成员之间共享的程度尚不清楚。我们在这里使用木聚糖作为模型表明,微生物群关键成员(例如卵形拟杆菌)共享复杂碳水化合物的分解产物取决于目标聚糖的复杂性。对卵形芽孢杆菌表达的广泛木聚糖降解装置的表征表明,人类肠道微生物群对多糖的分解比之前提出的模型要复杂得多,之前的模型基于含有有限单糖侧链的木聚糖的解构。
更新日期:2015-06-28
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