Pyrimidinone is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. An efficient silver-catalyzed intermolecular cyclization of 2-aminopyridines with various alkynoates has been developed. 2-Substituted 4H-pyrido[1,2-a]pyrimidin-4-ones containing a wide range of functional groups are synthesized in the standard conditions. This transformation is conducted under convenient conditions and affords products in good yields.

中文翻译：

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银催化的2-氨基吡啶和炔酸酯合成吡啶并[1,2-a]嘧啶-4-酮

嘧啶酮由于其广泛的生物活性而成为重要的含氮杂环之一。已经开发了一种有效的银催化的2-氨基吡啶与各种链烷酸酯的分子间环化。在标准条件下合成了含有广泛官能团的2-取代的4H-吡啶并[1,2-a]嘧啶-4-酮。该转化是在方便的条件下进行的，并提供了高收率的产品。