Ebola DNA vaccine is incorporated into PLGA‐PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.

中文翻译：

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使用微针贴片管理的PLGA-PLL /γPGA纳米颗粒上涂有DNA疫苗的埃博拉疫苗接种

埃博拉病毒DNA疫苗被掺入PLGA-PLL /γPGA纳米颗粒中，并使用微针（MN）贴剂施用于皮肤。与游离疫苗相比，纳米颗粒递送系统提高了疫苗的热稳定性和免疫原性。MN贴片的疫苗接种比肌肉注射产生更强的免疫反应。