脂肪族<i>N</i>取代的8元环状碳酸酯的两亲和亲水嵌段共聚物：生物医学应用的多功能高分子平台。,Biomacromolecules

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脂肪族N取代的8元环状碳酸酯的两亲和亲水嵌段共聚物：生物医学应用的多功能高分子平台。
Biomacromolecules ( IF 5.5 ) Pub Date : 2016-12-07 00:00:00 , DOI: 10.1021/acs.biomac.6b01463
Shrinivas Venkataraman ₁ , Jeremy P. K. Tan ₁ , Victor W. L. Ng ₁ , Eddy W. P. Tan ₁ , James L. Hedrick ₂ , Yi Yan Yang ₁

Affiliation

将亲水性组分，特别是胺和两性离子，引入到可降解的聚合物平台上，同时保持对聚合物组成的精确控制，一直是一个挑战。认识到这些亲水性残基在纳米生物医学领域的多个方面的重要性，本文提出了一种直接的合成路线，可从二乙醇胺衍生的功能八元氮中获得定义明确的两亲和亲水性可降解嵌段共聚物报道了取代的脂族环状碳酸酯。通过这种途径，可以跨聚合物主链掺入叔胺，仲胺和两性离子残基。显示了这些亲水性残基的pH响应性及其在开发药物递送载体中的效用，这些载体可满足各种模型药物（阿霉素和双氯芬酸钠盐）的特定要求。由于可降解聚合物中的亲水性成分在生物相互作用中起着至关重要的作用，因此这些材料为扩大脂肪族环状碳酸酯的范围和适用性提供了机会。我们采用这些功能性聚碳酸酯的方法将扩大可用于纳米生物医学的生物相容性和可生物降解合成材料的范围，包括药物和基因传递，抗微生物剂，

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Amphiphilic and Hydrophilic Block Copolymers from Aliphatic N-Substituted 8-Membered Cyclic Carbonates: A Versatile Macromolecular Platform for Biomedical Applications

Introduction of hydrophilic components, particularly amines and zwitterions, onto a degradable polymer platform, while maintaining precise control over the polymer composition, has been a challenge. Recognizing the importance of these hydrophilic residues in multiple aspects of the nanobiomedicine field, herein, a straightforward synthetic route to access well-defined amphiphilic and hydrophilic degradable block copolymers from diethanolamine-derived functional eight-membered N-substituted aliphatic cyclic carbonates is reported. By this route, tertiary amine, secondary amine, and zwitterion residues can be incorporated across the polymer backbone. Demonstration of pH-responsiveness of these hydrophilic residues and their utility in the development of drug-delivery vehicles, catered for the specific requirements of respective model drugs (doxorubicin and diclofenac sodium salt) are shown. As hydrophilic components in degradable polymers play crucial roles in the biological interactions, these materials offers opportunities to expand the scope and applicability of aliphatic cyclic carbonates. Our approach to these functional polycarbonates will expand the range of biocompatible and biodegradable synthetic materials available for nanobiomedicine, including drug and gene delivery, antimicrobials, and hydrophilic polymers as poly(ethylene glycol) (PEG) alternatives.

更新日期：2016-12-07

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