Ferrocene-based phosphine oxides with various substituents at phosphorous atoms were synthesized by Cu-catalyzed reductive coupling of ferrocenyl ketone-derived tosylhydrazones and H-phosphorus oxides. Followed by the reduction of ferrocene-based phosphine oxides, 1-substituted ferrocene-based phosphine ligand 7 and 1,1′-disubstituted ferrocene-based phosphine ligand 9 were obtained. Josiphos type ligand 8 were produced after ortho-lithiation of 7 and trapping with chlorodiphenyl phosphine or chlorodicyclohexylphosphine.

中文翻译：

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铜催化的二茂铁基酮衍生的甲苯磺酰hydr和H-磷氧化物的铜催化还原偶联合成二茂铁基膦配体

通过铜催化二茂铁基酮衍生的甲苯磺酰hydr和H-磷氧化物的还原反应，合成了在磷原子上具有多个取代基的二茂铁基氧化膦。接着还原二茂铁基氧化膦，得到1-取代的二茂铁基膦配体7和1，1'-二取代的二茂铁基膦配体9。Josiphos型配体8是在7的邻位锂化并用氯二苯基膦或氯二环己基膦捕获后制得的。