In the present work, a mild and simple synthesis of α-amino amides has been developed via the one-pot three-component ABC type Ugi reaction of a wide variety of aromatic aldehydes and primary aromatic amines, and two different aliphatic isocyanides. The reactions took place rapidly at room temperature in the presence of 1-propanephosphonic acid cyclic anhydride (T3P^®), rendering possible the highly efficient preparation of an α-amino amide library in medium to excellent yields. This study represents the first case in which T3P^® has been used in the Ugi reaction.

中文翻译：

---

丙基膦酸酐（T3P®）介导的Ugi型三组分反应的研究。有效合成α-氨基酰胺库

在目前的工作中，已经通过一种单锅三组分ABC型Ugi反应开发了一种温和而简单的α-氨基酰胺合成方法，该反应由多种芳族醛和伯芳族胺以及两种不同的脂族异氰酸酯组成。该反应发生迅速在室温下在1-丙烷膦酸环酐（T3P的存在^®），渲染可能的α氨基酰胺库在介质中的高效率的制备以优良的产率。该研究代表其中T3P第一壳体^®已经在Ugi反应被使用。