Incorporation of Soft Particles into Lipid Vesicles: Effects of Particle Size and Elasticity,Langmuir

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Incorporation of Soft Particles into Lipid Vesicles: Effects of Particle Size and Elasticity
Langmuir ( IF 3.7 ) Pub Date : 2016-12-02 00:00:00 , DOI: 10.1021/acs.langmuir.6b03184
Xin Yi ₁ , Huajian Gao ₁

Affiliation

The interaction between particles and lipid biomembranes plays an essential role in many fields such as endocytosis, drug delivery, and intracellular traffic. Here we conduct a theoretical study on the incorporation of elastic particles of different sizes and rigidities into a lipid vesicle through adhesive wrapping. It is shown that while the incorporation of relatively small particles involves smooth shape evolution, the vesicle wrapping of large particles exhibits a discontinuous shape transition, followed by a protrusion of the vesicle membrane at infinitesimal cost of elastic deformation energy. Moreover, softer particles require stronger adhesion energy to achieve successful internalization and delay the onset of discontinuous shape transition to a higher wrapping degree. Depending on the adhesion energy, particle-vesicle size, and rigidity ratios, and the spontaneous curvature of the vesicle, a rich variety of wrapping phase diagrams consisting of stable and metastable states of no-wrapping, partial-wrapping, and full-wrapping are established. The underlying mechanism of the discontinuous shape transformation of the vesicle and the relation between the uptake proneness and uptake efficiency are discussed. These results shed further light on the elasticity effects in cellular uptake of elastic particles and may provide rational design guidelines for controlled endocytosis and diagnostics delivery.

中文翻译：

软颗粒掺入脂质囊泡：粒径和弹性的影响

颗粒与脂质生物膜之间的相互作用在许多领域如内吞作用，药物递送和细胞内运输中起着至关重要的作用。在这里，我们进行了有关通过粘合剂包裹将不同大小和刚度的弹性颗粒掺入脂质囊泡的理论研究。结果表明，虽然相对小的颗粒的掺入会引起平滑的形状演变，但是大颗粒的囊泡包裹表现出不连续的形状转变，随后以最小的弹性变形能量代价使囊泡膜突出。此外，较软的颗粒需要较强的粘附能才能成功实现内在化，并将不连续形状转变的发生延迟到更高的包裹程度。根据粘附能，颗粒囊泡大小，，刚度比，囊泡的自发曲率，建立了由无包裹，部分包裹和完全包裹的稳定状态和亚稳态组成的各种包裹状态图。讨论了囊泡不连续形状转化的潜在机理以及摄取倾向与摄取效率之间的关系。这些结果进一步揭示了弹性颗粒在细胞摄取中的弹性效应，并可能为控制内吞作用和诊断传递提供合理的设计指导。讨论了囊泡不连续形状转化的潜在机理以及摄取倾向与摄取效率之间的关系。这些结果进一步揭示了弹性颗粒在细胞摄取中的弹性效应，并可能为控制内吞作用和诊断传递提供合理的设计指导。讨论了囊泡不连续形状转化的潜在机理以及摄取倾向与摄取效率之间的关系。这些结果进一步揭示了弹性颗粒在细胞摄取中的弹性效应，并可能为控制内吞作用和诊断传递提供合理的设计指导。

更新日期：2016-12-02

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