6-Nitrobenzo[a]pyrene, an environmental pollutant, was metabolized by human intestinal microflora to 6-nitrosobenzo[a]pyrene and 6-aminobenzo[a]pyrene. The two-electron reduction product 6-nitrosobenzo[a]pyrene exhibited strong direct-acting mutagenicity in the Salmonella typhimurium assay. These results imply that 6-nitrobenzo[a]pyrene can be hazardous to human health via a nitroreduction activation pathway and opens the possibility that other nitro-polycyclic aromatic hydrocarbons that are not direct-acting mutagens may be activated in vivo by a similar mechanism.

中文翻译：

---

6-硝基苯并[a] a的硝基还原：人类中的潜在激活途径。

6-硝基苯并[a] py是一种环境污染物，被人体肠道菌群代谢为6-亚硝基苯并[a] py和6-氨基苯并[a] py。在鼠伤寒沙门氏菌测定中，双电子还原产物6-亚硝基苯并[a] py表现出很强的直接作用诱变性。这些结果表明6-硝基苯并[a] py可能通过硝基还原活化途径对人体健康造成危害，并打开了可能通过类似机制在体内活化不是直接作用的诱变剂的其他硝基多环芳烃的可能性。