Asymmetric Catalytic Cascade Reactions for Constructing Diverse Scaffolds and Complex Molecules,Accounts of Chemical Research

当前位置： X-MOL 学术 › Acc. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Asymmetric Catalytic Cascade Reactions for Constructing Diverse Scaffolds and Complex Molecules
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2015-06-23 00:00:00 , DOI: 10.1021/acs.accounts.5b00217
Yao Wang ₁ , Hong Lu ₁ , Peng-Fei Xu ₁

Affiliation

With the increasing concerns about chemical pollution and sustainability of resources, among the significant challenges facing synthetic chemists are the development and application of elegant and efficient methods that enable the concise synthesis of natural products, drugs, and related compounds in a step-, atom- and redox-economic manner. One of the most effective ways to reach this goal is to implement reaction cascades that allow multiple bond-forming events to occur in a single vessel. This Account documents our progress on the rational design and strategic application of asymmetric catalytic cascade reactions in constructing diverse scaffolds and synthesizing complex chiral molecules.

中文翻译：

构架和复杂分子的不对称催化级联反应

随着人们对化学污染和资源可持续性的日益关注，合成化学家面临的重大挑战包括开发和应用优雅高效的方法，这些方法可以实现天然产物，药物和相关化合物的简捷合成。和氧化还原经济方式。达到此目标的最有效方法之一是实施反应级联反应，该反应级联反应允许在单个容器中发生多个键形成事件。该报告记录了我们在不对称催化级联反应的合理设计和战略应用方面的进展，该反应用于构建各种支架和合成复杂的手性分子。

更新日期：2015-06-23

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南