3-Amino-1,2,4-oxadiazole (3a) has been prepared from t-butoxycarbonylamino-1,2,4-oxadiazole (3h), and also from hydroxyguanidine and formyl fluoride. The amine is unexpectedly stable; on acid hydrolysis it gives hydroxyguanidine. 3-Cyano-1,2,4-oxadiazole (3m), prepared by dehydration of 1,2,4-oxadiazole-3-carboxamide (3l), is highly reactive but thermally stable. Some reactions of the amine (3a) and the nitrile (3m) are described.

中文翻译：

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3-氨基和3-氰基-1,2,4-恶二唑

由叔丁氧基羰基氨基-1，2，4-恶二唑（3h），也由羟基胍和甲酰氟制备3-氨基-1,2,4-恶二唑（3a）。胺出乎意料地稳定；经酸水解可得到羟基胍。通过1,2,4-恶二唑-3-羧酰胺（3l）脱水制得的3-氰基1,2,4-恶二唑（3m）具有高反应活性，但具有热稳定性。描述了胺（3a）和腈（3m）的一些反应。