Cyclohexane-fused octahydroquinolizine (COHQ) alkaloids present an unwonted carbon framework among alkaloids isolated from genus Myrioneuron, which featured with bridge-ring and hemiacetal groups. Continued chemical investigation of Myrioneuron faberi led to the isolation of four COHQ related structures, β-myrifabral C (1), α-myrifabral C (2), β-myrifabral D (3), and α-myrifabral D (4). 1 and 2 were inseparable hemiacetal epimers (cluster A), as did 3 and 4 (cluster B). The structures of 1–4 were elucidated on basis of MS and NMR spectra. In vitro, cluster A showed moderate inhibition activity against hepatitis C virus (HCV) replication with therapeutic index (CC₅₀/EC₅₀) of 74.0.

中文翻译：

---

Fabrioneuron faberi的环己烷融合八氢喹啉嗪生物碱的新发现

环己烷融合八氢喹啉（COHQ）生物碱在分离自Myrioneuron属的生物碱中呈现出未知的碳构架，该生物碱具有桥环和半缩醛基团。不断进行的Myrioneuron faberi的化学研究导致分离出四个与COHQ相关的结构，即β-myrifabralC（1），α-myrifabralC（2），β-myrifabralD（3）和α-myrifabralD（4）。1和2是密不可分的半缩醛差向异构体（集群A），而3和4（集群B）也是如此。根据MS和NMR光谱阐明了1-4的结构。在体外，簇A显示出对丙型肝炎病毒（HCV）复制的中等抑制活性，治疗指数（CC ₅₀ / EC ₅₀）为74.0。