The facile and rapid preparation of biocompatibility surface for biomedical materials has always been a goal in biomedical field. Catechol and its derivatives exhibit excellent adhesive properties, and alternating copolymers of basic amino acids such as poly(ornithine-valine) (Orn-Val) demonstrate superior biocompatibility and selectivity. Therefore, in this work, we employed the Ugi 4-component condensation (Ugi’ 4CC) method to introduce the catechol moieties into Orn-Val backbone, synthesizing the Orn-Val-OH with excellent adhesion properties and biocompatibility. We found that Orn-Val-OH can facilely and rapidly form the coatings on a variety of substrate surfaces, including titanium, glass, PDMS, and silicon wafers. Additionally, the concentration of Orn-Val-OH significantly influenced the hydrophilicity, protein adhesion, and the adhesion of red blood cells and platelets on silicon surface, while maintaining consistently excellent biocompatibility. These results demonstrate that Orn-Val-OH serves as a readily graftable, versatile biocompatible coating capable of enhancing the surface properties of biomedical materials.

中文翻译：

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一种用于增强生物医用材料表面生物相容性的简便通用涂层 Orn-Val-OH


生物医用材料生物相容性表面的简便快速制备一直是生物医学领域的目标。儿茶酚及其衍生物表现出优异的粘合性能，碱性氨基酸的交替共聚物如聚鸟氨酸-缬氨酸）（Orn-Val）表现出优异的生物相容性和选择性。因此，在这项工作中，我们采用 Ugi 4 组分缩合 （Ugi' 4CC） 方法将儿茶酚部分引入 Orn-Val 主链中，合成了具有优异粘附性能和生物相容性的 Orn-Val-OH。我们发现 Orn-Val-OH 可以方便、快速地在各种衬底表面形成涂层，包括钛、玻璃、PDMS 和硅晶片。此外，Orn-Val-OH 的浓度显着影响亲水性、蛋白质粘附以及红细胞和血小板在硅表面的粘附，同时保持始终如一的优异生物相容性。这些结果表明，Orn-Val-OH 是一种易于润滑、用途广泛的生物相容性涂层，能够增强生物医学材料的表面特性。