5-Amino-4-oxopentanoic acid (5-aminolevulinic acid) is a precursor in the biosynthesis of the biologically active porphyrins such as chlorophyll, bacteriochlorophyll, heme, etc. These systems are central in photosynthesis, oxygen transport, electron transport, etc. In this paper we describe a simple scheme to prepare any isotopomer of 5-aminolevulinic acid in a few steps in high yield. Using a similar scheme, levulinic acid can now also be prepared in any isotopomeric form. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

中文翻译：

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[1,2,3,4,5-13C5]-5-Amino-4-oxopentanoic酸（ALA）的制备-制备具有高同位素富集的任何13C-和15N-同位素的合成方案的设计

5-氨基-4-氧代戊酸（5-氨基乙酰丙酸）是叶绿素、细菌叶绿素、血红素等生物活性卟啉生物合成的前体。这些系统在光合作用、氧传输、电子传输等方面处于核心地位。在本文中，我们描述了一个简单的方案，可以通过几个步骤以高产率制备任何 5-氨基乙酰丙酸的同位素异构体。使用类似的方案，乙酰丙酸现在也可以制备成任何同位素形式。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)