3-Aminobicyclo[1.1.1]pentane-1-carboxylic Acid Derivatives: Synthesis and Incorporation into Peptides,European Journal of Organic Chemistry

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3-Aminobicyclo[1.1.1]pentane-1-carboxylic Acid Derivatives: Synthesis and Incorporation into Peptides
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2004-02-01 , DOI: 10.1002/ejoc.200300554
Michael Pätzel , Maximilian Sanktjohanser , Alexander Doss , Peter Henklein , Günter Szeimies

We have developed an efficient synthesis of derivatives of 3-aminobicyclo[1.1.1]pentane-1-carboxylic acid (7, 8, 9, and 10) starting from [1.1.1]propellane (3). These rigid analogues of γ-aminobutyric acid have been incorporated into linear and cyclic peptides using solution chemistry and solid-phase techniques. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

中文翻译：

3-氨基双环[1.1.1]戊烷-1-羧酸衍生物：合成并掺入肽中

我们开发了一种以 [1.1.1] 丙烷 (3) 为原料高效合成 3-氨基双环 [1.1.1] 戊烷-1-羧酸（7、8、9 和 10）衍生物的方法。这些 γ-氨基丁酸的刚性类似物已使用溶液化学和固相技术结合到线性和环状肽中。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

更新日期：2004-02-01

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