Macrocyclic hosts which can bind two guests simultaneously with high affinity, such as, cucurbit[8]uril, are highly useful for a wide range of application by acting as noncovalent connectors. However, the integration of stimuli-controlled release properties into such robust noncovalent connectors would be even more desirable. Here, we introduce Naph-SAC4A, a naphthyl-extended deep-cavity azocalix[4]arene with hypoxia-responsiveness, which exhibits exceptional 1:2 hosting abilities for organic dyes in aqueous solution with affinities ranging from 1014 to 1016 M–2. Furthermore, Naph-SAC4A was employed as a robust while hypoxia-cleavable noncovalent connector to construct linear supramolecular polymers and crosslinked supramolecular hydrogels. Both structures exhibit responsiveness to hypoxic stimuli. With its high-affinity 1:2 recognition, unique hypoxia-responsiveness, and easy accessibility, Naph-SAC4A holds great potential for smart supramolecular polymeric materials.

中文翻译：

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基于萘基-偶氮卡利[4]芳烃的高亲和力 1：2 识别及其作为可切割非共价连接器在构建响应性超分子聚合物材料中的应用


大环宿主可以同时以高亲和力结合两个客体，例如葫芦[8]uril，通过充当非共价连接器，对广泛的应用非常有用。然而，将刺激控制释放特性整合到如此强大的非共价连接器中将更加可取。在这里，我们介绍了 Naph-SAC4A，一种具有缺氧反应性的萘基延伸深腔偶氮卡利[4]芳烃，它对有机染料在水溶液中表现出卓越的 1：2 承载能力，亲和力范围为 1014 至 1016 M–2。此外，Naph-SAC4A 被用作稳健且缺氧可切割的非共价连接器，以构建线性超分子聚合物和交联超分子水凝胶。两种结构都表现出对缺氧刺激的反应性。凭借其高亲和力 1：2 识别、独特的缺氧响应性和易于获取性，Naph-SAC4A 在智能超分子聚合物材料中具有巨大潜力。