Generalizable Molecular Switch Designs for In Vivo Continuous Biosensing,Accounts of Chemical Research

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Generalizable Molecular Switch Designs for In Vivo Continuous Biosensing
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2025-02-15 , DOI: 10.1021/acs.accounts.4c00721
Jason Saunders ₁ , Ian A P Thompson ₁ , Hyongsok Tom Soh _{1,

2,

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Affiliation

Continuous biosensors have the potential to transform medicine, enabling healthcare to be more preventative and personalized as compared to the current standard of reactive diagnostics. Realizing this transformative potential requires biosensors that can function continuously in vivo without sample preparation and deliver molecular specificity, sensitivity, and high temporal resolution. Molecular switches stand out as a promising solution for creating such sensors for the continuous detection of many different types of molecules. Molecular switches are target-binding receptors designed such that binding causes a conformational change in the switch’s structure. This structure switching induces a measurable signal change via reporters incorporated into the molecular switch, enabling highly specific, label-free sensing. However, there remains an outstanding need for generalizable switch designs that can be adapted for the detection of a wide range of molecular targets.

中文翻译：

用于体内连续生物传感的通用分子开关设计

连续生物传感器有可能改变医学，与当前的反应式诊断标准相比，使医疗保健更具预防性和个性化。实现这种变革潜力需要生物传感器能够在体内连续工作，无需样品制备，并提供分子特异性、灵敏度和高时间分辨率。分子开关是创建用于连续检测许多不同类型分子的传感器的一种有前途的解决方案。分子开关是靶标结合受体，其设计使得结合会导致开关结构的构象变化。这种结构切换通过分子开关中的报告基因诱导可测量的信号变化，从而实现高度特异性、无标记的传感。然而，对可适应检测各种分子靶标的通用开关设计仍然存在巨大需求。

更新日期：2025-02-15

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