Hydromethylation of Unactivated Olefins,Journal of the American Chemical Society

当前位置： X-MOL 学术 › J. Am. Chem. Soc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hydromethylation of Unactivated Olefins
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2015-06-19 , DOI: 10.1021/jacs.5b05144
Hai T. Dao ₁ , Chao Li ₁ , Quentin Michaudel ₁ , Brad D. Maxwell ₂ , Phil S. Baran ₁

Affiliation

A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly “edit” complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.

中文翻译：

未活化烯烃的氢甲基化

提出了烯烃氢甲基化的经典未解决问题的解决方案。这种高度化学选择性的方法可以耐受不稳定和反应性的化学官能团，并使用一组简单的试剂。一系列烯烃，包括单、二和三取代的烯烃，都可以顺利地进行氢甲基化。这种温和的协议可用于简化特定目标的合成或直接“编辑”复杂的天然产物和其他先进材料。该方法还适用于放射性和稳定标记甲基的简单安装。

更新日期：2015-06-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南