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Portable Acoustic Holographic Optical Waveguide Device for Phototherapy
ACS Photonics ( IF 6.5 ) Pub Date : 2025-01-27 , DOI: 10.1021/acsphotonics.4c02189
Runyu Wang, Qibo Lin, Zhaoxi Li, Xiongwei Wei, Chenxue Hou, Han Shan, Xiaofei Luo, Xize Yu, Zeyu Chen, Xiheng Hu, Chunlong Fei

Photodynamic therapy and photothermal therapy have emerged as indispensable modalities to treat diseases. However, their efficacy is hindered by the substantial light scattering within tissues, preventing light transmission effectively to targeted lesion sites. Various existing devices aimed at mitigating light scattering typically exhibit invasiveness and complexity. In this work, we propose an approach that utilizes a portable acoustic holographic optical waveguide device to mitigate light scattering by manipulating the refractive index within tissues. This manipulation allows in situ modulation of scattered light, thereby promoting the concentration of photon energy. We demonstrated that the device can mitigate light scattering in a medium through simulation and optical imaging experiments. Second, we demonstrated in both photothermal and photodynamic experiments that the device can enhance the rate of temperature rise in the medium and the rate of singlet oxygen (1O2) generation, respectively. It is foreseeable that this versatility in overcoming light scattering can augment the outcomes of phototherapy, offering a noninvasive, portable, and robust method.

中文翻译:


用于光疗的便携式声全息光波导装置



光动力疗法和光热疗法已成为治疗疾病不可或缺的方式。然而,它们的功效受到组织内大量光散射的阻碍,从而阻止了光有效地传输到目标病变部位。旨在减轻光散射的各种现有设备通常表现出侵入性和复杂性。在这项工作中,我们提出了一种方法,该方法利用便携式声学全息光波导器件,通过操纵组织内的折射率来减轻光散射。这种操作允许对散射光进行原位调制,从而促进光子能量的集中。我们通过模拟和光学成像实验证明了该设备可以减轻介质中的光散射。其次,我们在光热和光动力实验中证明,该装置可以分别提高介质中的升温速率和单线态氧 ( 1 O 2 ) 的产生速率。可以预见,这种克服光散射的多功能性可以增强光疗的结果,提供一种无创、便携且强大的方法。
更新日期:2025-01-28
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