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Epigenetic modification increases skeletal muscle resilience to metabolic stress
Nature Metabolism ( IF 18.9 ) Pub Date : 2025-01-27 , DOI: 10.1038/s42255-024-01211-8


Genetic deletion of Kdm2a or pharmacological blockade of KDM2A, a histone 3 demethylase, in skeletal muscle shifts fuel preference from glucose to lipids under cold challenge in mice fed a high-fat diet. KDM2A loss increases the proportion of mitochondria-rich, slow-twitch myofibres, conferring flexible protection against metabolic stress.

中文翻译:


表观遗传修饰增加了骨骼肌对代谢应激的恢复力



在喂食高脂肪饮食的小鼠中,骨骼肌中 Kdm2a 的基因缺失或 KDM2A(一种组蛋白 3 去甲基化酶)的药理学阻断使燃料偏好在寒冷攻击下从葡萄糖转移到脂质。KDM2A 缺失增加了富含线粒体的慢肌纤维的比例,从而为代谢应激提供了灵活的保护。
更新日期:2025-01-27
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