In the field of chemical biology, DNA origami has been actively researched. This technique, which involves folding DNA strands like origami to assemble them into desired shapes, has made it possible to create complex nanometer-sized structures, marking a major breakthrough in nanotechnology. On the other hand, controlling the folding mechanisms and folded structures of proteins or shorter peptides has been challenging. However, recent advances in techniques such as protein origami, peptide origami, and de novo design peptides have made it possible to construct various nanoscale structures and create functional molecules. These approaches suggest the emergence of new molecular design principles, which can be termed "molecular origami". In this review, we provide an overview of recent research trends in protein/peptide origami and DNA/RNA origami and explore potential future applications of molecular origami technologies in electrochemical biosensors.

中文翻译：

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分子折纸：设计未来的功能分子。


在化学生物学领域，DNA 折纸得到了积极的研究。这项技术涉及折叠折纸等 DNA 链以将它们组装成所需的形状，使创建复杂的纳米级结构成为可能，标志着纳米技术的重大突破。另一方面，控制蛋白质或较短肽的折叠机制和折叠结构一直具有挑战性。然而，蛋白质折纸、肽折纸和从头设计肽等技术的最新进展使得构建各种纳米级结构和创建功能分子成为可能。这些方法表明了新的分子设计原则的出现，可以称为“分子折纸”。在这篇综述中，我们概述了蛋白质/肽折纸和 DNA/RNA 折纸的最新研究趋势，并探讨了分子折纸技术在电化学生物传感器中的潜在未来应用。