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Electrochemical Biosensor for Point-of-care Testing Aqueous Molecular Hydrogen
Electrochimica Acta ( IF 5.5 ) Pub Date : 2025-01-26 , DOI: 10.1016/j.electacta.2025.145756
Wenjin Li, Yanxin Gao, Cong Han, Xuantong Luo, Jian Zhao, Hang Luo, Jiayue Yang, Liyun Zhang
Electrochimica Acta ( IF 5.5 ) Pub Date : 2025-01-26 , DOI: 10.1016/j.electacta.2025.145756
Wenjin Li, Yanxin Gao, Cong Han, Xuantong Luo, Jian Zhao, Hang Luo, Jiayue Yang, Liyun Zhang
Hydrogen (H2) is not only a crucial energy carrier but also a therapeutically significant gas with broad biological implications. Developing a sensitive, convenient, and reliable method for detecting and quantifying molecular hydrogen in aqueous solutions is essential to meet the growing demands of hydrogen medicine and health research. In this study, we present a portable hydrogenase-based electrochemical biosensor designed for detecting trace amounts of hydrogen in various aqueous environments. Our electrochemical biosensor offers highly sensitive detection of aqueous H2 within a linear range of 0-3 μM, with a limit of detection (LOD) of 33 nM. The entire detection process is completed in just five minutes, and the sensor retains over 80% of its activity even after six months of storage at 4°C. This biosensor features exceptional sensitivity, stability, and robustness, making it scalable, adaptable, and portable. It is ideally suited for detecting a variety of beverages and clinical samples with low LOD and high reliability. These advancements pave the way for new commercial products in the hydrogen medicine and health industry and facilitate progress in developing diverse enzyme-based biosensors.
中文翻译:
用于床旁检测水分子氢的电化学生物传感器
氢气 (H 2 ) 不仅是一种重要的能量载体,而且还是一种具有广泛生物学意义的具有治疗意义的气体。开发一种灵敏、方便、可靠的方法来检测和定量水溶液中的氢分子,对于满足氢医学和健康研究日益增长的需求至关重要。在这项研究中,我们提出了一种基于氢化酶的便携式电化学生物传感器,旨在检测各种水环境中的痕量氢。我们的电化学生物传感器可在 0-3 μM 的线性范围内对 H 2 水溶液进行高灵敏度检测,检测限 (LOD) 为 33 nM。整个检测过程仅需 5 分钟即可完成,即使在 4°C 下存放 6 个月后,传感器仍能保持 80% 以上的活性。 该生物传感器具有卓越的灵敏度、稳定性和稳健性,使其可扩展、适应性强且便携。它非常适合检测各种低 LOD 和高可靠性的饮料和临床样品。这些进步为氢医学和健康行业的新商业产品铺平了道路,并促进了开发各种基于酶的生物传感器的进展。
更新日期:2025-01-26
中文翻译:
用于床旁检测水分子氢的电化学生物传感器
氢气 (H 2 ) 不仅是一种重要的能量载体,而且还是一种具有广泛生物学意义的具有治疗意义的气体。开发一种灵敏、方便、可靠的方法来检测和定量水溶液中的氢分子,对于满足氢医学和健康研究日益增长的需求至关重要。在这项研究中,我们提出了一种基于氢化酶的便携式电化学生物传感器,旨在检测各种水环境中的痕量氢。我们的电化学生物传感器可在 0-3 μM 的线性范围内对 H 2 水溶液进行高灵敏度检测,检测限 (LOD) 为 33 nM。整个检测过程仅需 5 分钟即可完成,即使在 4°C 下存放 6 个月后,传感器仍能保持 80% 以上的活性。 该生物传感器具有卓越的灵敏度、稳定性和稳健性,使其可扩展、适应性强且便携。它非常适合检测各种低 LOD 和高可靠性的饮料和临床样品。这些进步为氢医学和健康行业的新商业产品铺平了道路,并促进了开发各种基于酶的生物传感器的进展。