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Acute Effects of a Single Bout of Strength and Endurance Exercise on Vitamin D Metabolites in Young Adults.
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2025-01-24 , DOI: 10.1249/mss.0000000000003658
Mats Peder Mosti,Norun Aagård,Astrid Kamilla Stunes,Cathrine Langlie Brobakken,Martin Siksjø Brevig,Miriam K Gustafsson,Per Medbøe Thorsby,Eivind Wang,Unni Syversen

PURPOSE The effect of exercise on serum concentration of vitamin D metabolites remains inconclusive, with studies reporting deviating results. This study evaluated the acute effect of a single session of two specific exercise forms; strength training (ST) and high-intensity interval training (HIIT), on circulating 25-hydroxyvitamin D (25(OH)D), free25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)2D), and skeletal muscle vitamin D receptor (VDR) gene expression, in healthy adults. METHODS Thirty-nine participants (19 women and 20 men, age 21-30 years) completed a single bout of ST and HIIT exercise, separated by two weeks. Serum concentration of total 25(OH)D, free25(OH)D and 1,25(OH)2D were assessed before exercise, immediately after, and 3 hours and 24 hours after each session. Muscle biopsies were obtained at rest (1st visit), and at 3 hours and 24 hours post ST and HIIT, and analyzed for VDR gene expression. Repeated measures ANOVA was used to assess serum concentration across time, while paired samples t-test was used for muscle VDR gene expression analyses. RESULTS Serum concentration of 25(OH)D or free 25(OH)D did not change after either exercise mode when correcting for plasma volume alterations. 1,25(OH)2D was reduced by 13.1 ± 18.3 pmol/L and 7.1 ± 9.6 pmol/L immediately after ST and HIIT, respectively (P < 0.001). Muscle VDR mRNA expression increased after ST by 3.1 ± 1.8 (3 hr) and 2.2 ± 1.7 (24 hr) fold change (P < 0.05). CONCLUSIONS One single session of ST or HIIT did not alter serum concentration of 25(OH)D and free 25(OH)D when correcting for plasma volume changes. Both exercise modes caused a transient reduction in 1,25(OH)2D suggesting utilization of 1,25(OH)2D by muscle cells following exercise. Elevated VDR gene expression following ST suggests a functional role of VDR in fast-twitch muscle fibers.

中文翻译:


单次力量和耐力运动对年轻人维生素 D 代谢物的急性影响。



目的 运动对血清维生素 D 代谢物浓度的影响仍无定论,研究报告的结果有所不同。本研究评估了两种特定锻炼形式的单次训练的急性效果;力量训练 (ST) 和高强度间歇训练 (HIIT),对健康成人循环 25-羟基维生素 D (25(OH)D)、游离 25(OH)D 和 1,25-二羟基维生素 D (1,25(OH)2D) 和骨骼肌维生素 D 受体 (VDR) 基因表达。方法 39 名参与者 (19 名女性和 20 名男性,年龄 21-30 岁) 完成了一次 ST 和 HIIT 锻炼,间隔两周。在运动前、运动后立即以及每次训练后 3 小时和 24 小时评估总 25(OH)D 、游离 25(OH)D 和 1,25(OH)2D 的血清浓度。在静息 (第 1 次就诊) 以及 ST 和 HIIT 后 3 小时和 24 小时进行肌肉活检,并分析 VDR 基因表达。重复测量方差分析用于评估随时间变化的血清浓度,而配对样本 t 检验用于肌肉 VDR 基因表达分析。结果 在校正血浆容量变化时,血清浓度 25(OH)D 或游离 25(OH)D 在两种运动模式后均无变化。ST 和 HIIT 后 1,25(OH)2D 分别降低 13.1 ± 18.3 pmol/L 和 7.1 ± 9.6 pmol/L(P < 0.001)。ST 后肌肉 VDR mRNA 表达增加 3.1 ± 1.8 (3 hr) 和 2.2 ± 1.7 (24 hr) 倍变化 (P < 0.05)。结论 在校正血浆容量变化时,单次 ST 或 HIIT 不会改变血清 25(OH)D 和游离 25(OH)D 浓度。两种运动模式都导致 1,25(OH)2D 的短暂减少,表明运动后肌肉细胞利用 1,25(OH)2D。 ST 后 VDR 基因表达升高表明 VDR 在快肌纤维中的功能作用。
更新日期:2025-01-24
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