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Deployment and transcriptional evaluation of nitisinone, an FDA‐approved drug, to control bed bugs
Pest Management Science ( IF 3.8 ) Pub Date : 2025-01-25 , DOI: 10.1002/ps.8614
Marcos Sterkel, Joshua Tompkin, Coby Schal, Luiza R. M. Guerra, Grasielle C. D. Pessoa, Pedro L. Oliveira, Joshua B. Benoit
Pest Management Science ( IF 3.8 ) Pub Date : 2025-01-25 , DOI: 10.1002/ps.8614
Marcos Sterkel, Joshua Tompkin, Coby Schal, Luiza R. M. Guerra, Grasielle C. D. Pessoa, Pedro L. Oliveira, Joshua B. Benoit
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BACKGROUNDBed bugs are blood‐feeders that rapidly proliferate into large indoor infestations. Their bites can cause allergies, secondary infections and psychological stress, among other problems. Although several tactics for their management have been used, bed bugs continue to spread worldwide wherever humans reside. This is mainly due to human‐mediated transport and their high resistance to several classes of insecticides. New treatment options with novel modes of action are required for their control. In this study, we evaluated the use of nitisinone (NTBC), an FDA‐approved drug, for bed bug control in an insecticide‐susceptible (HH) and an insecticide‐resistant (CIN) population.RESULTSAlthough NTBC was lethal to both populations when administered orally or applied topically in very low doses, we observed a slight but significant resistance in the CIN population. Transcriptomic analysis in both populations indicated that NTBC treatment elicited a broad suppression of genes associated with RNA post‐transcriptional modifications, translation, endomembrane system, protein post‐translational modifications and protein folding. The CIN population exhibited higher adenosine triphosphate (ATP) production and xenobiotic detoxification. Feeding studies on a mouse model suggest that NTBC could be used as a control method of bed bugs by host treatment.CONCLUSIONThe results indicate that NTBC can be used as a new active ingredient for bed bug control by topical or oral treatment and shed light on the molecular mechanisms of suppressed tyrosine metabolism following NTBC treatment. © 2025 Society of Chemical Industry.
中文翻译:
NITISINONE(一种 FDA 批准的药物)的部署和转录评估,用于控制臭虫
背景 虫子是以血液为食的,会迅速增殖成大型室内侵扰。它们的叮咬会导致过敏、继发感染和心理压力等问题。尽管已经使用了多种管理策略,但臭虫继续传播到世界各地,无论人类居住在哪里。这主要是由于人类介导的运输以及它们对几类杀虫剂的高度耐药性。需要具有新作用方式的新治疗方案来控制它们。在这项研究中,我们评估了 FDA 批准的药物尼替西农 (NTBC) 在杀虫剂敏感 (HH) 和杀虫剂耐药 (CIN) 人群中用于臭虫控制的使用情况。结果尽管 NTBC 在口服或以极低剂量局部给药时对两个人群都是致命的,但我们在 CIN 人群中观察到轻微但显着的耐药性。两个群体的转录组学分析表明,NTBC 处理引起了与 RNA 转录后修饰、翻译、内膜系统、蛋白质翻译后修饰和蛋白质折叠相关的基因的广泛抑制。CIN 人群表现出较高的三磷酸腺苷 (ATP) 产生和外源性解毒。小鼠模型的摄食研究表明,NTBC 可以通过宿主处理用作臭虫的控制方法。结论结果表明,NTBC 可作为局部或口服治疗防治臭虫的新活性成分,阐明 NTBC 治疗后酪氨酸代谢抑制的分子机制。© 2025 化工学会.
更新日期:2025-01-25
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
NITISINONE(一种 FDA 批准的药物)的部署和转录评估,用于控制臭虫
背景 虫子是以血液为食的,会迅速增殖成大型室内侵扰。它们的叮咬会导致过敏、继发感染和心理压力等问题。尽管已经使用了多种管理策略,但臭虫继续传播到世界各地,无论人类居住在哪里。这主要是由于人类介导的运输以及它们对几类杀虫剂的高度耐药性。需要具有新作用方式的新治疗方案来控制它们。在这项研究中,我们评估了 FDA 批准的药物尼替西农 (NTBC) 在杀虫剂敏感 (HH) 和杀虫剂耐药 (CIN) 人群中用于臭虫控制的使用情况。结果尽管 NTBC 在口服或以极低剂量局部给药时对两个人群都是致命的,但我们在 CIN 人群中观察到轻微但显着的耐药性。两个群体的转录组学分析表明,NTBC 处理引起了与 RNA 转录后修饰、翻译、内膜系统、蛋白质翻译后修饰和蛋白质折叠相关的基因的广泛抑制。CIN 人群表现出较高的三磷酸腺苷 (ATP) 产生和外源性解毒。小鼠模型的摄食研究表明,NTBC 可以通过宿主处理用作臭虫的控制方法。结论结果表明,NTBC 可作为局部或口服治疗防治臭虫的新活性成分,阐明 NTBC 治疗后酪氨酸代谢抑制的分子机制。© 2025 化工学会.