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The antioxidant property of CAPE depends on TRPV1 channel activation in microvascular endothelial cells
Redox Biology ( IF 10.7 ) Pub Date : 2025-01-20 , DOI: 10.1016/j.redox.2025.103507
Miltha Hidalgo, Bárbara Railef, Vania Rodríguez, Carolina Navarro, Vanessa Rubio, Jorge Meneses-Pacheco, Sandra Soto-Alarcón, Christine Kreindl, Carolina Añazco, Leandro Zuñiga, Omar Porras
Redox Biology ( IF 10.7 ) Pub Date : 2025-01-20 , DOI: 10.1016/j.redox.2025.103507
Miltha Hidalgo, Bárbara Railef, Vania Rodríguez, Carolina Navarro, Vanessa Rubio, Jorge Meneses-Pacheco, Sandra Soto-Alarcón, Christine Kreindl, Carolina Añazco, Leandro Zuñiga, Omar Porras
Caffeic acid phenethyl ester (CAPE) is a hydrophobic phytochemical typically found in propolis that acts as an antioxidant, anti-inflammatory and cardiovascular protector, among several other properties. However, the molecular entity responsible for recognising CAPE is unknown, and whether that molecular interaction is involved in developing an antioxidant response in the target cells remains an unanswered question. Herein, we hypothesized that a subfamily of TRP ion channels works as the molecular entity that recognizes CAPE at the plasma membrane and allows a fast shift in the antioxidant capacity of intact endothelial cells (EC).
中文翻译:
CAPE 的抗氧化特性取决于微血管内皮细胞中 TRPV1 通道的激活
咖啡酸苯乙酯 (CAPE) 是一种疏水性植物化学物质,通常存在于蜂胶中,具有抗氧化、抗炎和心血管保护剂等多种特性。然而,负责识别 CAPE 的分子实体尚不清楚,并且该分子相互作用是否参与在靶细胞中产生抗氧化反应仍然是一个悬而未决的问题。在此,我们假设 TRP 离子通道的一个亚家族作为分子实体,在质膜上识别 CAPE,并允许完整内皮细胞 (EC) 的抗氧化能力快速转变。
更新日期:2025-01-20
中文翻译:
CAPE 的抗氧化特性取决于微血管内皮细胞中 TRPV1 通道的激活
咖啡酸苯乙酯 (CAPE) 是一种疏水性植物化学物质,通常存在于蜂胶中,具有抗氧化、抗炎和心血管保护剂等多种特性。然而,负责识别 CAPE 的分子实体尚不清楚,并且该分子相互作用是否参与在靶细胞中产生抗氧化反应仍然是一个悬而未决的问题。在此,我们假设 TRP 离子通道的一个亚家族作为分子实体,在质膜上识别 CAPE,并允许完整内皮细胞 (EC) 的抗氧化能力快速转变。