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Caloric restriction exacerbates renal post-ischemic injury and fibrosis by modulating mTORC1 signaling and autophagy
Redox Biology ( IF 10.7 ) Pub Date : 2025-01-16 , DOI: 10.1016/j.redox.2025.103500
Lang Shi, Hongchu Zha, Juan Zhao, Haiqian An, Hua Huang, Yao Xia, Ziyu Yan, Zhixia Song, Jiefu Zhu

This study investigates the effects of caloric restriction (CR) on renal injury and fibrosis following ischemia-reperfusion injury (IRI), with a focus on the roles of the mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling and autophagy.

中文翻译:


热量限制通过调节 mTORC1 信号传导和自噬加剧肾脏缺血后损伤和纤维化



本研究调查了热量限制 (CR) 对缺血再灌注损伤 (IRI) 后肾损伤和纤维化的影响,重点是雷帕霉素复合物 1 (mTORC1) 信号传导和自噬的机制/哺乳动物靶点的作用。
更新日期:2025-01-16
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