当前位置: X-MOL 学术Med. Sci. Sports Exercise › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of Three Different Distance/Elevation-Gain Ultra-Trail Races on Red Blood Cell Oxidative Stress and Senescence, and Blood Rheology.
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2025-01-21 , DOI: 10.1249/mss.0000000000003653
Romain Carin,Elie Nader,Nicolas Bouscaren,Philippe Connes,Floran Begue,Grégorie Lebeau,Aurélie Paulo-Ramos,Guillaume Descombes,Laetitia Berly,Frederique Modrzyk,Emilie Blond,Sébastien Racinais,Guillaume Y Millet,Olivier Meilhac,Philippe Rondeau

PURPOSE Red blood cells (RBCs) senescence and blood rheology during ultra-endurance running events appear to be impacted differently depending on the race distance. The physiological mechanisms underlying these differences are poorly understood. METHODS We investigated the effects of three different ultra-trail running races performed in La Reunion Island (Mascareignes, "the 70 km", 70 km/4,000 m D+; Trail Du Bourbon, "the 100 km", 100 km/6,090 m D+; Diagonale des Fous, "the 170 km", 170 km/10,500 m D+) on RBC oxidative stress, RBC senescence and blood rheology in 66 finishers (18 "70 km", 24 "100 km", 24 "170 km"). RESULTS We observed a decrease in RBC antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase and catalase) positively related to the race distance, and an increase in RBC H2O2 and isoprostane levels after the three races. However, RBC H2O2 and isoprostane levels were found to be higher after the 70 km compared to the 170 km and the 100 km races. RBC phosphatidylserine externalization increased over baseline value after the 70 km only. Chymotrypsin-like and trypsin-like activities of the RBC proteasome were decreased after all races compared to before. RBC-derived microparticles (RBC-MPs) were increased after the 170 km and the 70 km races. Despite increased RBC senescence markers, RBC deformability increased after the three races. Blood viscosity was differently impacted by the three races with a decrease at low shear rate after the two longest races (the 170 km and the 100 km), and an increase at high shear rate after the shortest one (the 70 km). CONCLUSIONS Our results confirm that ultra endurance running events differently impact on RBC senescence markers and blood viscosity depending on the race distance, and suggest that RBC oxidative stress could play a key role in the observed alterations.

中文翻译:


三种不同距离/海拔增益的超越野赛对红细胞氧化应激和衰老以及血液流变学的影响。



目的 超耐力跑步活动期间的红细胞 (RBC) 衰老和血液流变学似乎受到的影响不同,具体取决于比赛距离。这些差异背后的生理机制知之甚少。方法 我们调查了在留尼汪岛进行的三种不同的超越野跑比赛的效果(Mascareignes,“70 公里”,70 公里/4,000 米 D+;Trail Du Bourbon,“100 公里”,100 公里/6,090 米 D+;Diagonale des Fous,“170 公里”,170 公里/10,500 米 D+)对 66 个育肥猪(18 个“70 公里”、24 个“100 公里”、24 个“170 公里”)的红细胞氧化应激、红细胞衰老和血液流变学的影响。结果 我们观察到 RBC 抗氧化酶活性 (超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶) 与比赛距离呈正相关,而 RBC H2O2 和异前列腺素水平在 3 场比赛后增加。然而,与 170 公里和 100 公里比赛相比,70 公里后发现 RBC H2O2 和异前列烷水平更高。仅在 70 km 后,RBC 磷脂酰丝氨酸外化增加于基线值。与之前相比,所有比赛后 RBC 蛋白酶体的胰凝乳蛋白酶样和胰蛋白酶样活性均降低。RBC 衍生微粒 (RBC-MPs) 在 170 公里和 70 公里比赛后增加。尽管 RBC 衰老标志物增加,但 3 场比赛后 RBC 变形性增加。血液黏度受 3 场比赛的影响不同,最长的两场比赛(170 公里和 100 公里)后低剪切速率降低,最短的一场(70 公里)后高剪切速率增加。 结论 我们的结果证实,超耐力跑步项目对 RBC 衰老标志物和血液粘度的影响不同,具体取决于比赛距离,并表明 RBC 氧化应激可能在观察到的变化中发挥关键作用。
更新日期:2025-01-21
down
wechat
bug