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Impact of Sex on Cardiac Functional Adaptation to Different Modes of Exercise Training: A Randomized Cross-Over Study.
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2025-01-21 , DOI: 10.1249/mss.0000000000003654
Louise H Naylor,Channa E Marsh,Hannah J Thomas,Barbara A Maslen,Julie Collis,Leanne Lester,Daniel J Green
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2025-01-21 , DOI: 10.1249/mss.0000000000003654
Louise H Naylor,Channa E Marsh,Hannah J Thomas,Barbara A Maslen,Julie Collis,Leanne Lester,Daniel J Green
PURPOSE
We hypothesized that male and female volunteers would exhibit distinct changes in cardiac morphology, systolic, and diastolic function following endurance (END) and resistance (RES) training.
METHODS
Thirty-eight females and 26 males participated in a randomized cross-over design trial in which all participants completed 12-weeks END and RES, separated by a 12-week washout. Echocardiograms assessed morphology (left ventricular mass, LVM), systolic function (ejection fraction, EF, and global longitudinal strain, GLS), diastolic function (mitral valve velocities, E, A; tissue Doppler velocities, e', a'), and left atrial volume.
RESULTS
Males responded to RES by increasing LVM (Δ 9.1 ± 14.3 g, P = 0.005), while E/e' increased (Δ 0.74 ± 1.08, P = 0.004, indicating a decline in diastolic function). There were no significant changes in females following RES. In response to END, LVM increased in both males (Δ 8.8 ± 15.7 g, P = 0.008) and females (Δ 6.5 ± 12.5 g, P = 0.004), with no difference in E/e' (Δ -0.29 ± 0.90) in males but a significant difference in females (Δ -0.39 ± 1.06, P = 0.012, indicating an improvement in diastolic function). Systolic function was not impacted significantly by END or RES in either sex.
CONCLUSIONS
Our data suggests that females were less responsive to RES training than males, that RES increased LVM and caused a decline in diastolic function (i.e. an increase in E/e') in males, whereas END improved E/e' (i.e. decreased) in females. These data suggest that sex differences exist in cardiac structural and functional adaptations to different forms of exercise training.
中文翻译:
性别对不同运动训练模式的心脏功能适应的影响:一项随机交叉研究。
目的 我们假设男性和女性志愿者在耐力 (END) 和阻力 (RES) 训练后心脏形态、收缩和舒张功能会表现出明显的变化。方法 38 名女性和 26 名男性参加了一项随机交叉设计试验,其中所有参与者都完成了 12 周的 END 和 RES,间隔 12 周的清除。超声心动图评估形态学(左心室质量,LVM)、收缩功能(射血分数,EF 和整体纵向应变,GLS)、舒张功能(二尖瓣速度,E、A;组织多普勒速度,e'、a')和左心房容积。结果 男性对 RES 的反应是增加 LVM (Δ 9.1 ± 14.3 g,P = 0.005),而 E/e' 增加 (Δ 0.74 ± 1.08,P = 0.004,表明舒张功能下降)。RES 后女性没有显着变化。响应 END 后,男性 (Δ 8.8 ± 15.7 g,P = 0.008) 和女性 (Δ 6.5 ± 12.5 g,P = 0.004) 的 LVM 均增加,男性的 E/e' (Δ -0.29 ± 0.90) 无差异,但女性差异显著 (Δ -0.39 ± 1.06,P = 0.012,表明舒张功能改善)。END 或 RES 对任一性别的收缩功能均无显著影响。结论 我们的数据表明,女性对 RES 训练的反应不如男性,RES 增加了 LVM 并导致男性舒张功能下降(即 E/e' 增加),而 END 改善了女性的 E/e' (即减少)。这些数据表明,对不同形式的运动训练的心脏结构和功能适应存在性别差异。
更新日期:2025-01-21
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
性别对不同运动训练模式的心脏功能适应的影响:一项随机交叉研究。
目的 我们假设男性和女性志愿者在耐力 (END) 和阻力 (RES) 训练后心脏形态、收缩和舒张功能会表现出明显的变化。方法 38 名女性和 26 名男性参加了一项随机交叉设计试验,其中所有参与者都完成了 12 周的 END 和 RES,间隔 12 周的清除。超声心动图评估形态学(左心室质量,LVM)、收缩功能(射血分数,EF 和整体纵向应变,GLS)、舒张功能(二尖瓣速度,E、A;组织多普勒速度,e'、a')和左心房容积。结果 男性对 RES 的反应是增加 LVM (Δ 9.1 ± 14.3 g,P = 0.005),而 E/e' 增加 (Δ 0.74 ± 1.08,P = 0.004,表明舒张功能下降)。RES 后女性没有显着变化。响应 END 后,男性 (Δ 8.8 ± 15.7 g,P = 0.008) 和女性 (Δ 6.5 ± 12.5 g,P = 0.004) 的 LVM 均增加,男性的 E/e' (Δ -0.29 ± 0.90) 无差异,但女性差异显著 (Δ -0.39 ± 1.06,P = 0.012,表明舒张功能改善)。END 或 RES 对任一性别的收缩功能均无显著影响。结论 我们的数据表明,女性对 RES 训练的反应不如男性,RES 增加了 LVM 并导致男性舒张功能下降(即 E/e' 增加),而 END 改善了女性的 E/e' (即减少)。这些数据表明,对不同形式的运动训练的心脏结构和功能适应存在性别差异。