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Pinnatifone A, isolated from Syringa pinnatifolia (Oleaceae), exhibits inhibitory activity against phytopathogenic fungi and can be employed to formulate a soluble concentrate agent
Pest Management Science ( IF 3.8 ) Pub Date : 2025-01-20 , DOI: 10.1002/ps.8661
Wenhao Wang, Wei Chen, Puxing Hou, Ruyu Li, Pei Li, Yahan Fan, Hua Wu, Zhiqing Ma

BACKGROUNDIn the realm of plant diseases, those caused by fungi and oomycetes are particularly challenging to manage, resulting in significant economic losses. There exist diverse active substances in natural products and developing them into fungicides holds great significance. At the initial phase of our research, we discovered that Syringa pinnatifolia extract demonstrates broad‐spectrum inhibitory activity against phytopathogenic fungi.RESULTSS. pinnatifolia extracts showed inhibitory activity against phytopathogenic fungi in vivo and in vitro, especially Valsa mali and Botrytis cinerea. Totals of eight compounds were isolated by bio‐guided isolation (SCX‐1 to SCX‐8). Among these compounds, 3‐methoxy‐4‐hydroxybenzaldehyde (SCX‐2) and pinnatifone A (SCX‐8) were found to have excellent antifungal activities against phytopathogenic fungi, the half maximal effective concentration (EC50) of SCX‐2 against V. mali was 45.34 μg/mL, the EC50 of compound SCX‐8 against B. cinerea was 9.25 μg/mL. Here a formulation of a soluble concentrate agent is presented for the prevention and control of tomato gray mold. This formulation included 45% S. pinnatifolia extract (containing 2.1% pinnatifone A), 16% benzyl alcohol, 24% absolute ethanol, 5% ethylene glycol, and 10% pesticide emulsifier No. 602. The preparation exhibited good protective and curative efficacies against tomato gray mold at a concentration of 100 μg/mL, with efficacies of 65.32% and 54.83%.CONCLUSIONOur findings provide valuable insights for the structural modification of active compounds derived from S. pinnatifolia and lay a foundation for the development of novel botanical fungicide products utilizing S. pinnatifolia as a raw material. © 2025 Society of Chemical Industry.

中文翻译:


从 Syringa pinnatifolia(油橄榄科)中分离的 Pinnatifone A 对植物病原真菌具有抑制活性,可用于配制可溶性浓缩剂



背景在植物病害领域,由真菌和卵菌引起的病害特别难以管理,导致重大经济损失。天然产物中存在多种活性物质,将其开发成杀菌剂具有重要意义。在我们研究的初始阶段,我们发现丁香提取物对植物病原真菌具有广谱抑制活性。结果。Pinnatifolia 提取物在体内和体外均显示出对植物病原真菌的抑制活性,尤其是 Valsa mali 和 Botrytis cinerea。通过生物引导分离共分离出 8 种化合物 (SCX-1 至 SCX-8)。在这些化合物中,3-甲氧基-4-羟基苯甲醛 (SCX-2) 和羽片酮 A (SCX-8) 对植物病原真菌具有优异的抗真菌活性,SCX-2 对苹果弧菌的半数最大有效浓度 (EC50) 为 45.34 μg/mL,化合物 SCX-8 对灰葡萄孢杆菌的 EC50 为 9.25 μg/mL。这里提出了一种用于预防和控制番茄灰霉病的可溶性浓缩剂配方。该配方包括 45% 松叶松树提取物(含 2.1% 松果酮 A)、16% 苯甲醇、24% 无水乙醇、5% 乙二醇和 10% 杀虫剂乳化剂 602 号。该制剂对100 μg/mL浓度的番茄灰霉病具有良好的保护和治疗效果,分别分别为65.32%和54.83%。结论研究结果为松叶草活性化合物的结构修饰提供了有价值的见解,为以松叶草为原料开发新型植物杀菌剂产品奠定了基础。© 2025 化工学会.
更新日期:2025-01-20
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