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A novel micromagnetic carrier-modified integrated fixed-film activated sludge system for simultaneous efficient removal of tetracycline and mitigation of antibiotic resistance genes proliferation and dissemination
Water Research ( IF 11.4 ) Pub Date : 2025-01-20 , DOI: 10.1016/j.watres.2025.123166
Yuan-Mo Zhu, Yi Xue, Kai Jin, Yongsheng Chen, Hongqiang Ren, Ke Xu

To address the challenge of antibiotic-containing wastewater, a novel micromagnetic carrier-modified integrated fixed-film activated sludge system (MC-IFAS) was developed for treating tetracycline (TC)-containing swine wastewater in this study. The magnetic effects of the MC significantly enhanced TC removal by improving TC biosorption and biodegradation in both the suspended activated sludge and the carrier-attached biofilm in the MC-IFAS. The increased electrostatic attraction and number of binding sites in both the activated sludge and the biofilm enhanced their TC biosorption capacities, particularly in the activated sludge. Additionally, the MC shifted microbial community assembly from stochastic to deterministic factors, amplifying the selection pressure induced by TC on the microbial community, thus enriching organic compound-degrading genera Dokdonella and TM7a; it also stimulated ammonia monooxygenase-mediated and cytochrome P450-mediated TC metabolisms and upregulated functional genes encoding lyases, transferases, hydrolases, and oxidoreductases- all of which enhanced TC biodegradation capacity in the MC-IFAS, particularly in the biofilm. While enhancing TC removal efficiency, the MC mitigated the proliferation and dissemination of antibiotic resistance genes (ARGs) by suppressing the abundances of ARGs hosts, the mobile genetic element intI1, and genes encoding ATP-binding cassette transporters and putative transposases. This study provides novel insights into the large-scale applications of magnetic field-enhanced TC removal strategies.

中文翻译:


一种新型微磁载体改性集成固定膜活性污泥系统,可同时有效去除四环素并减轻抗生素耐药基因的增殖和传播



为了应对含抗生素废水的挑战,本研究开发了一种新型微磁载体改性集成固定膜活性污泥系统 (MC-IFAS),用于处理含四环素 (TC) 的猪废水。MC 的磁效应通过改善 MC-IFAS 中悬浮活性污泥和载体附着生物膜中的 TC 生物吸附和生物降解,显着增强了 TC 去除。活性污泥和生物膜中静电吸引力的增加和结合位点的数量增强了它们的 TC 生物吸附能力,尤其是在活性污泥中。此外,MC 将微生物群落组装从随机因素转变为确定因素,放大了 TC 对微生物群落诱导的选择压力,从而丰富了有机化合物降解属 Dokdonella 和 TM7a;它还刺激氨单加氧酶介导和细胞色素 P450 介导的 TC 代谢,并上调编码裂解酶、转移酶、水解酶和氧化还原酶的功能基因——所有这些都增强了 TC 在 MC-IFAS 中的生物降解能力,尤其是在生物膜中。MC 在提高 TC 去除效率的同时,通过抑制 ARGs 宿主、移动遗传元件 intI1 以及编码 ATP 结合盒转运蛋白和推定转座酶的基因的丰度来减轻抗生素耐药基因 (ARGs) 的增殖和传播。本研究为磁场增强 TC 去除策略的大规模应用提供了新的见解。
更新日期:2025-01-20
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