Nature Human Behaviour ( IF 21.4 ) Pub Date : 2025-01-20 , DOI: 10.1038/s41562-024-02097-y
Selina Kikkenborg Berg, Helle Wallach-Kildemoes, Line Ryberg Rasmussen, Ulrikka Nygaard, Nina Marie Birk, Henning Bundgaard, Annette Kjær Ersbøll, Lau Caspar Thygesen, Susanne Dam Nielsen, Anne Vinggaard Christensen
Healthcare use among adolescents after vaccination against SARS-CoV-2 is unknown. In a real-life register-based cohort study (trial NCT04786353), healthcare use was compared among Pfizer-BioNTech BNT162b2 COVID-19 vaccinated and unvaccinated 12–18-year-olds. First-dose-vaccinated (between 1 May and 30 September 2021) adolescents were sex and age matched 1:1 with unvaccinated adolescents. Outcomes were visits to emergency rooms, hospitalization, and visits to general practitioners and specialist practitioners. The prior event rate ratio (PERR) was applied. The study finds that boys had fewer visits to general practitioners (PERR 0.93, 95% confidence interval (CI) 0.89–0.99) after the first vaccine. Up to 56 days after the second dose, vaccinated boys had lower rates of visits to specialist practitioners (0.88, 95% CI 0.79–0.99); after 57–182 days, vaccinated girls and boys had higher rates of visits to emergency rooms (1.22, 95% CI 1.08–1.39; 1.17, 95% CI 1.07–1.31) and to general practitioners (1.17, 95% CI 1.12–1.21; 1.17, 95% CI 1.13–1.22). Furthermore, vaccinated boys had higher rates of visits to specialist practitioners (1.23, 95% CI 1.08–1.39). Estimates were close to one and do not indicate that BNT162b2 leads to a practically meaningful increase in healthcare use among vaccinated adolescents.
中文翻译:
在基于国家登记册的丹麦队列中,接种 SARS-CoV-2 疫苗的 12-18 岁青少年与未接种疫苗的青少年的医疗保健使用情况
青少年接种 SARS-CoV-2 疫苗后的医疗保健使用情况尚不清楚。在一项基于真实注册的队列研究(试验 NCT04786353)中,比较了接种辉瑞-BioNTech BNT162b2 COVID-19 疫苗和未接种疫苗的 12-18 岁青少年的医疗保健使用情况。第一剂疫苗接种者(2021 年 5 月 1 日至 9 月 30 日期间)的青少年与未接种疫苗的青少年的性别和年龄 1:1 匹配。结局是急诊室就诊、住院以及全科医生和专科医生就诊。应用既往事件率比 (PERR)。研究发现,男孩在第一次接种疫苗后去看全科医生的次数较少 (PERR 0.93,95% 置信区间 (CI) 0.89-0.99)。在第二剂接种后 56 天内,接种疫苗的男孩看专科医生的比率较低 (0.88,95% CI 0.79-0.99);57-182 天后,接种疫苗的女孩和男孩急诊室就诊率较高(1.22,95% CI 1.08-1.39;1.17,95% CI 1.07-1.31)和全科医生就诊率(1.17,95% CI 1.12-1.21;1.17,95% CI 1.13-1.22)。此外,接种疫苗的男孩去看专科医生的比率更高 (1.23,95% CI 1.08-1.39)。估计值接近 1,并不表明 BNT162b2 导致接种疫苗的青少年医疗保健使用量实际有意义增加。