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Aldolase A: the broker of glycolysis
Nature Metabolism ( IF 18.9 ) Pub Date : 2025-01-20 , DOI: 10.1038/s42255-024-01202-9
Luiza Martins Nascentes Melo, Feyza Cansiz, Alpaslan Tasdogan
Nature Metabolism ( IF 18.9 ) Pub Date : 2025-01-20 , DOI: 10.1038/s42255-024-01202-9
Luiza Martins Nascentes Melo, Feyza Cansiz, Alpaslan Tasdogan
Aldolase A is one of the glycolytic enzymes that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an ATP-consuming process. Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic metabolic plasticity of cancer cells.
中文翻译:
醛缩酶 A:糖酵解的中间体
醛缩酶 A 是调节癌细胞增殖的糖酵解酶之一。一项新的研究将醛缩酶 A 确定为一个关键节点,当在癌细胞中受到抑制时,它会将糖酵解变成消耗 ATP 的过程。靶向醛缩酶 A 诱导不平衡的糖酵解可以克服癌细胞固有的代谢可塑性。
更新日期:2025-01-20
中文翻译:
醛缩酶 A:糖酵解的中间体
醛缩酶 A 是调节癌细胞增殖的糖酵解酶之一。一项新的研究将醛缩酶 A 确定为一个关键节点,当在癌细胞中受到抑制时,它会将糖酵解变成消耗 ATP 的过程。靶向醛缩酶 A 诱导不平衡的糖酵解可以克服癌细胞固有的代谢可塑性。