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The continuing significance of chiral agrochemicals
Pest Management Science ( IF 3.8 ) Pub Date : 2025-01-17 , DOI: 10.1002/ps.8655
Peter Jeschke

Chemical crop protection is one of the most cost‐effective methods for agriculture, as crop failures can be prevented, and sustainable growth can be enabled regardless of the seasons. Agricultural production must be significantly increased in the future to meet the food needs of a growing world population. However, the continued loss of established active ingredients due to consumer perceptions, changing needs of farmers and ever‐changing regulatory requirements is higher than annually new active ingredients introduced to the market. The development of innovative active ingredients is therefore essential to continuously improve the selectivity, efficacy and favorable environmental profile of agrochemicals. Molecules with stereogenic centers can be considered here, as they often have different properties than non‐chiral molecules. Natural products and their congeners are still a valuable source of inspiration for chiral agrochemicals. However, only a few novel chiral agrochemicals are currently produced on an industrial scale as pure stereoisomers or in enriched form. As of 2018, around 43% of the 35 chiral products introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers. Surprisingly, the proportion of chiral agrochemicals is in the same order of magnitude as in the time frame from 2007 to 2017 with around 42%, respectively. This report therefore provides an overview of the continued importance of chiral agrochemicals brought to market in the last 6 years and describes the inherent related challenges of modern agrochemicals through the management of key aspects arising from innovative crop protection products. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

中文翻译:


手性农用化学品的持续意义



化学作物保护是农业最具成本效益的方法之一,因为可以防止作物歉收,并且无论季节如何,都可以实现可持续增长。未来必须大幅增加农业产量,以满足不断增长的世界人口的粮食需求。然而,由于消费者的看法、农民不断变化的需求和不断变化的监管要求,现有活性成分的持续损失高于每年投放市场的新活性成分。因此,创新活性成分的开发对于不断提高农用化学品的选择性、功效和良好的环境状况至关重要。这里可以考虑具有立体中心的分子,因为它们通常具有与非手性分子不同的性质。天然产物及其同系物仍然是手性农用化学品的宝贵灵感来源。然而,目前只有少数新型手性农用化学品以纯立体异构体或富集形式以工业规模生产。截至 2018 年,在推向市场的 35 种手性产品(除草剂、杀菌剂、杀虫剂、杀螨剂和杀线虫剂)中,约有 43% 的分子含有一个或多个立体中心,其中近 69% 已作为对映异构体或立体异构体的外消旋混合物销售。令人惊讶的是,手性农用化学品的比例与 2007 年至 2017 年同期的比例相同,分别约为 42%。 因此,本报告概述了过去 6 年中手性农用化学品进入市场的持续重要性,并通过管理创新作物保护产品产生的关键方面,描述了现代农用化学品的固有相关挑战。© 2025 作者。由John Wiley & Sons Ltd代表化学工业协会出版的《害虫管理科学》。
更新日期:2025-01-17
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