当前位置: X-MOL 学术Nat. Metab. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recommendations for mitochondria transfer and transplantation nomenclature and characterization
Nature Metabolism ( IF 18.9 ) Pub Date : 2025-01-16 , DOI: 10.1038/s42255-024-01200-x
Jonathan R. Brestoff, Keshav K. Singh, Katia Aquilano, Lance B. Becker, Michael V. Berridge, Eric Boilard, Andrés Caicedo, Clair Crewe, José Antonio Enríquez, Jianqing Gao, Åsa B. Gustafsson, Kazuhide Hayakawa, Maroun Khoury, Yun-Sil Lee, Daniele Lettieri-Barbato, Patricia Luz-Crawford, Heidi M. McBride, James D. McCully, Ritsuko Nakai, Jiri Neuzil, Martin Picard, Alexander G. Rabchevsky, Anne-Marie Rodriguez, Shiladitya Sengupta, Alexander J. Sercel, Toshio Suda, Michael A. Teitell, Alain R. Thierry, Rong Tian, Melanie Walker, Minghao Zheng

Intercellular mitochondria transfer is an evolutionarily conserved process in which one cell delivers some of their mitochondria to another cell in the absence of cell division. This process has diverse functions depending on the cell types involved and physiological or disease context. Although mitochondria transfer was first shown to provide metabolic support to acceptor cells, recent studies have revealed diverse functions of mitochondria transfer, including, but not limited to, the maintenance of mitochondria quality of the donor cell and the regulation of tissue homeostasis and remodelling. Many mitochondria-transfer mechanisms have been described using a variety of names, generating confusion about mitochondria transfer biology. Furthermore, several therapeutic approaches involving mitochondria-transfer biology have emerged, including mitochondria transplantation and cellular engineering using isolated mitochondria. In this Consensus Statement, we define relevant terminology and propose a nomenclature framework to describe mitochondria transfer and transplantation as a foundation for further development by the community as this dynamic field of research continues to evolve.



中文翻译:


线粒体转移和移植命名和表征的建议



细胞间线粒体转移是一个进化上保守的过程,其中一个细胞在没有细胞分裂的情况下将其部分线粒体输送到另一个细胞。这个过程具有不同的功能,具体取决于所涉及的细胞类型以及生理或疾病环境。尽管线粒体转移首先被证明为受体细胞提供代谢支持,但最近的研究揭示了线粒体转移的多种功能,包括但不限于维持供体细胞的线粒体质量以及调节组织稳态和重塑。许多线粒体转移机制已被使用各种名称进行描述,从而对线粒体转移生物学产生混淆。此外,已经出现了几种涉及线粒体转移生物学的治疗方法,包括线粒体移植和使用分离线粒体的细胞工程。在本共识声明中,我们定义了相关术语并提出了一个命名框架,以描述线粒体转移和移植,作为随着这一充满活力的研究领域的不断发展,社区进一步发展的基础。

更新日期:2025-01-16
down
wechat
bug