Metal–organic frameworks (MOFs) have been shown to be great alternatives to traditional porous materials in various chemical applications, and they have been very widely studied for biomedical applications in the past decade specifically for drug storage. After our review published in 2011 [Keskin and Kızılel, Ind. Eng. Chem. Res. 2011, 50 (4), 1799–1812, 10.1021/ie101312k], we have witnessed a very fast growth not only in the number and variety of MOFs but also in their usage across a broad spectrum of biomedical fields. With the recent integration of molecular modeling and data science approaches to the experimental studies, biomedical applications of MOFs have been significantly accelerated positioning them as pivotal components in the regenerative medicine, medical imaging, and diagnostics. In this review, we visited the diverse biomedical applications of MOFs considering the recent experimental and computational efforts on drug storage and delivery, bioimaging, and biosensing. We focused on the underlying mechanisms governing the molecular interactions between MOFs and biological systems and discussed both the opportunities and challenges in the field to highlight the potential of MOFs in advanced therapeutics for cancer and neurological diseases.

中文翻译：

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重新审视金属-有机框架的生物医学应用


金属有机框架 （MOF） 已被证明是各种化学应用中传统多孔材料的绝佳替代品，并且在过去十年中，它们已被广泛研究用于生物医学应用，特别是用于药物储存。在我们于 2011 年发表的评论之后 [Keskin 和 Kızılel， Ind.工程化学。Res.2011， 50 （4）， 1799–1812， 10.1021/ie101312k]，我们见证了 MOF 的数量和种类的快速增长，而且它们在广泛的生物医学领域的使用也非常迅速。随着最近将分子建模和数据科学方法整合到实验研究中，MOF 的生物医学应用得到了显著加速，使其成为再生医学、医学成像和诊断的关键组成部分。在这篇综述中，考虑到最近在药物储存和递送、生物成像和生物传感方面的实验和计算工作，我们考察了 MOF 的各种生物医学应用。我们重点研究了控制 MOF 与生物系统之间分子相互作用的潜在机制，并讨论了该领域的机遇和挑战，以突出 MOF 在癌症和神经系统疾病高级治疗中的潜力。