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Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2025-01-13 , DOI: 10.1016/j.jare.2025.01.021
Yameng Cui, Jingwen Liu, Xi Wang, Yulin Wu, Yunhan Chang, Xin Hu, Wei Zhao
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2025-01-13 , DOI: 10.1016/j.jare.2025.01.021
Yameng Cui, Jingwen Liu, Xi Wang, Yulin Wu, Yunhan Chang, Xin Hu, Wei Zhao
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The acidic microenvironment caused by excessive lactate accumulation could inhibit immune lymphocytes antitumor activity and promote the immune escape of tumor cells. Baicalin is an active flavonoid isolated from Scutellaria baicalensis Georgi, a traditional Chinese medicinal herb with antioxidant and anti-inflammatory properties.
中文翻译:
黄芩苷通过减少肿瘤微环境中的乳酸积累来减弱口腔鳞状细胞癌的免疫逃逸
乳酸过度积累引起的酸性微环境可抑制免疫淋巴细胞的抗肿瘤活性,促进肿瘤细胞的免疫逃逸。黄芩苷是从 Scutellaria baicalensis Georgi 中分离的一种活性类黄酮,Scutellaria baicalensis Georgi 是一种具有抗氧化和抗炎特性的传统中草药。
更新日期:2025-01-13
中文翻译:

黄芩苷通过减少肿瘤微环境中的乳酸积累来减弱口腔鳞状细胞癌的免疫逃逸
乳酸过度积累引起的酸性微环境可抑制免疫淋巴细胞的抗肿瘤活性,促进肿瘤细胞的免疫逃逸。黄芩苷是从 Scutellaria baicalensis Georgi 中分离的一种活性类黄酮,Scutellaria baicalensis Georgi 是一种具有抗氧化和抗炎特性的传统中草药。