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Sleep Deprivation Elevates Resting and Exercise Blood Pressures and Augments Pressor Response at Exercise Onset.
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2024-12-30 , DOI: 10.1249/mss.0000000000003640
Amane Hori,Xin Su,Shota Sagasaki,Ryuji Saito,Kenichi Suijo,Seiko Miyata,Daisuke Hasegawa,Masaki Mizuno,Norio Hotta
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2024-12-30 , DOI: 10.1249/mss.0000000000003640
Amane Hori,Xin Su,Shota Sagasaki,Ryuji Saito,Kenichi Suijo,Seiko Miyata,Daisuke Hasegawa,Masaki Mizuno,Norio Hotta
PURPOSE
Sleep deprivation and elevated blood pressure (BP) increase the risk of cardiovascular diseases. However, the effects of sleep deprivation on BP response, especially at exercise onset remain unclear. We aimed to elucidate the effects of experimental sleep deprivation (ESD) on resting and exercise BPs, including that at exercise onset, and investigate whether a night-time nap during ESD changes the ESD-altered BP.
METHODS
Twelve healthy young men underwent 2-min submaximal isometric elbow flexion (IEF) exercise to measure BP after 7 days of normal sleep (control trial), 24-h ESD (ESD trial), and ESD with a 2-h night-time nap (ESD + NAP trial), which were randomly performed.
RESULTS
ESD significantly elevated the mean arterial pressure (MAP) at rest (85.8 ± 8.0 to 93.3 ± 5.1 mmHg, P = 0.003) and at the last minute of IEF (116.9 ± 13.0 to 126.2 ± 11.8 mmHg, P = 0.003) compared with that observed in the control trial. At IEF onset (the initial 15 s), ESD significantly elevated the MAP (88.7 ± 12.6 to 103.1 ± 8.8 mmHg, P < 0.001) and augmented the MAP responsiveness from baseline, compared with that observed in the control trial (Δ2.9 ± 11.4 to Δ9.8 ± 6.6 mmHg, P = 0.017). The MAP responsiveness in the ESD + NAP trial (Δ7.3 ± 5.2 mmHg) was not significantly different from that in the control trial (P = 0.165) and the ESD trial (P = 0.129).
CONCLUSIONS
ESD significantly elevated both resting BP and the BP during submaximal isometric exercise and significantly augmented the initial pressor response to the exercise. A 2-h night-time nap during ESD appears to be insufficient to completely attenuate ESD-induced augmented pressor responses.
中文翻译:
睡眠剥夺会提高静息和运动血压,并增强运动开始时的升压反应。
目的 睡眠剥夺和血压 (BP) 升高会增加患心血管疾病的风险。然而,睡眠剥夺对血压反应的影响,尤其是在运动开始时仍不清楚。我们旨在阐明实验性睡眠剥夺 (ESD) 对静息和运动血压的影响,包括运动开始时的血压,并研究 ESD 期间的夜间小睡是否会改变 ESD 改变的血压。方法 12 名健康年轻男性接受了 2 分钟次最大等长肘屈曲 (IEF) 运动,以测量正常睡眠 7 天后的血压(对照试验), 随机进行 24 小时 ESD(ESD 试验)和 ESD 夜间小睡 2 小时(ESD + NAP 试验)。结果 与对照试验相比,ESD 在静息时 (85.8 ± 8.0 至 93.3 ± 5.1 mmHg,P = 0.003) 和 IEF 最后一分钟(116.9 ± 13.0 至 126.2 ± 11.8 mmHg,P = 0.003)的平均动脉压 (MAP) 显着升高。在 IEF 发作时(最初的 15 秒),ESD 显着升高 MAP (88.7 ± 12.6 至 103.1 ± 8.8 mmHg,P < 0.001),并增强 MAP 相对于基线的反应性,与对照试验中观察到的相比 (Δ2.9 ± 11.4 至 Δ9.8 ± 6.6 mmHg,P = 0.017)。ESD + NAP 试验中的 MAP 反应性 (Δ7.3 ± 5.2 mmHg) 与对照试验 (P = 0.165) 和 ESD 试验 (P = 0.129) 无显著差异。结论 ESD 在次最大等长运动期间显着升高静息血压和血压,并显着增加对运动的初始升压反应。ESD 期间 2 小时的夜间小睡似乎不足以完全减弱 ESD 诱导的增强加压反应。
更新日期:2024-12-30
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
睡眠剥夺会提高静息和运动血压,并增强运动开始时的升压反应。
目的 睡眠剥夺和血压 (BP) 升高会增加患心血管疾病的风险。然而,睡眠剥夺对血压反应的影响,尤其是在运动开始时仍不清楚。我们旨在阐明实验性睡眠剥夺 (ESD) 对静息和运动血压的影响,包括运动开始时的血压,并研究 ESD 期间的夜间小睡是否会改变 ESD 改变的血压。方法 12 名健康年轻男性接受了 2 分钟次最大等长肘屈曲 (IEF) 运动,以测量正常睡眠 7 天后的血压(对照试验), 随机进行 24 小时 ESD(ESD 试验)和 ESD 夜间小睡 2 小时(ESD + NAP 试验)。结果 与对照试验相比,ESD 在静息时 (85.8 ± 8.0 至 93.3 ± 5.1 mmHg,P = 0.003) 和 IEF 最后一分钟(116.9 ± 13.0 至 126.2 ± 11.8 mmHg,P = 0.003)的平均动脉压 (MAP) 显着升高。在 IEF 发作时(最初的 15 秒),ESD 显着升高 MAP (88.7 ± 12.6 至 103.1 ± 8.8 mmHg,P < 0.001),并增强 MAP 相对于基线的反应性,与对照试验中观察到的相比 (Δ2.9 ± 11.4 至 Δ9.8 ± 6.6 mmHg,P = 0.017)。ESD + NAP 试验中的 MAP 反应性 (Δ7.3 ± 5.2 mmHg) 与对照试验 (P = 0.165) 和 ESD 试验 (P = 0.129) 无显著差异。结论 ESD 在次最大等长运动期间显着升高静息血压和血压,并显着增加对运动的初始升压反应。ESD 期间 2 小时的夜间小睡似乎不足以完全减弱 ESD 诱导的增强加压反应。