当前位置:
X-MOL 学术
›
Med. Sci. Sports Exercise
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Alternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women.
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2024-12-30 , DOI: 10.1249/mss.0000000000003627
Mingxian Chen,Yuan Zhang,Xinkai Yu,Qun Zuo
Medicine & Science in Sports & Exercise ( IF 4.1 ) Pub Date : 2024-12-30 , DOI: 10.1249/mss.0000000000003627
Mingxian Chen,Yuan Zhang,Xinkai Yu,Qun Zuo
PURPOSE
Irisin plays an important role in bone-muscle crosstalk. The aim of this study was to elucidate the association of long-term exercise induced irisin response with body composition and bone mineral density in postmenopausal women.
METHODS
We recruited 29 postmenopausal women (age: 62.67 ± 3.9 years) without regular exercise habits to participate in a 24-week program of alternating aerobic and resistance training exercise. Blood samples, body composition and bone mineral density were measured before and after exercise intervention.
RESULTS
Upper and lower limb bone density (P = 0.004, P = 0.039), calf circumference (P = 0.001), circulating levels of irisin (P = 0.003) and osteocalcin (P < 0.001) increased by exercise. Whereas, waist circumference (P = 0.000), blood osteoprotegerin (OPG) (P = 0.041), receptor activator of NF-κB ligand (RANKL) (P < 0.001), RANKL/OPG ratio (P < 0.001) and estradiol levels (P = 0.003) decreased by training, respectively. According to the observed changes in the measured variables, the irisin circulating levels were significantly and separately related to upper limb BMD (r = 0.462, P = 0.006), lower limb BMD (r = 0.566, P = 0.001), total BMD (r = 0.490, P = 0.008) and T score of DAX (r = 0.489, P = 0.010). The increase in serum irisin levels was found to be positively and separately related to upper limb BMD (r = 0.414, P = 0.026), total BMD (r = 0.453, P = 0.014), calf circumference (r = 0.400, P = 0.031), and ASM/height2 (r = 0.309, P = 0.031) improvements.
CONCLUSIONS
Long-term alternating exercise training improves bone density, body composition and circulating irisin levels in postmenopausal women, and irisin would mediate bone-muscle crosstalk to exert positive effect of exercise on bone health in postmenopausal women.
中文翻译:
有氧运动与阻力运动交替进行可改善绝经后妇女的骨密度和循环鸢膜蛋白水平。
目的 鸢尾素在骨肌串扰中起重要作用。本研究的目的是阐明长期运动诱导的鸢尾素反应与绝经后妇女身体成分和骨密度的关系。方法 我们招募了 29 名没有规律运动习惯的绝经后妇女 (年龄:62.67 ± 3.9 岁) 参加为期 24 周的有氧和阻力交替训练计划。在运动干预前后测量血样、体成分和骨密度。结果 运动后上肢和下肢骨密度 (P = 0.004,P = 0.039)、小腿围 (P = 0.001)、鸢尾素 (P = 0.003) 和骨钙素 (P < 0.001) 水平增加。而腰围 (P = 0.000) 、血骨保护素 (OPG) (P = 0.041)、NF-κB 配体受体激活剂 (RANKL) (P < 0.001)、RANKL/OPG 比值 (P < 0.001) 和雌二醇水平 (P = 0.003) 分别通过训练降低。根据观察到的测量变量变化,鸢尾素循环水平与上肢 BMD (r = 0.462,P = 0.006)、下肢 BMD (r = 0.566,P = 0.001)、总 BMD (r = 0.490,P = 0.008) 和 DAX 的 T 评分 (r = 0.489,P = 0.010) 显著相关。发现血清鸢尾素水平的增加与上肢 BMD (r = 0.414,P = 0.026)、总 BMD (r = 0.453,P = 0.014)、小腿围 (r = 0.400,P = 0.031) 和 ASM/身高 2 (r = 0.309,P = 0.031) 改善呈正相关。结论 长期交替运动训练可改善绝经后妇女的骨密度、体成分和循环鸢尾素水平,鸢尾素会介导骨肌串扰,发挥运动对绝经后妇女骨骼健康的积极影响。
更新日期:2024-12-30
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
有氧运动与阻力运动交替进行可改善绝经后妇女的骨密度和循环鸢膜蛋白水平。
目的 鸢尾素在骨肌串扰中起重要作用。本研究的目的是阐明长期运动诱导的鸢尾素反应与绝经后妇女身体成分和骨密度的关系。方法 我们招募了 29 名没有规律运动习惯的绝经后妇女 (年龄:62.67 ± 3.9 岁) 参加为期 24 周的有氧和阻力交替训练计划。在运动干预前后测量血样、体成分和骨密度。结果 运动后上肢和下肢骨密度 (P = 0.004,P = 0.039)、小腿围 (P = 0.001)、鸢尾素 (P = 0.003) 和骨钙素 (P < 0.001) 水平增加。而腰围 (P = 0.000) 、血骨保护素 (OPG) (P = 0.041)、NF-κB 配体受体激活剂 (RANKL) (P < 0.001)、RANKL/OPG 比值 (P < 0.001) 和雌二醇水平 (P = 0.003) 分别通过训练降低。根据观察到的测量变量变化,鸢尾素循环水平与上肢 BMD (r = 0.462,P = 0.006)、下肢 BMD (r = 0.566,P = 0.001)、总 BMD (r = 0.490,P = 0.008) 和 DAX 的 T 评分 (r = 0.489,P = 0.010) 显著相关。发现血清鸢尾素水平的增加与上肢 BMD (r = 0.414,P = 0.026)、总 BMD (r = 0.453,P = 0.014)、小腿围 (r = 0.400,P = 0.031) 和 ASM/身高 2 (r = 0.309,P = 0.031) 改善呈正相关。结论 长期交替运动训练可改善绝经后妇女的骨密度、体成分和循环鸢尾素水平,鸢尾素会介导骨肌串扰,发挥运动对绝经后妇女骨骼健康的积极影响。