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The stereoselective bioactivity and mechanism of indoxacarb against Spodoptera frugiperda
Pest Management Science ( IF 3.8 ) Pub Date : 2025-01-09 , DOI: 10.1002/ps.8628
Haoming Guo, Nan Xiao, Zhixuan Wang, Yabo Liang, Xueke Liu, Peng Wang, Donghui Liu
Pest Management Science ( IF 3.8 ) Pub Date : 2025-01-09 , DOI: 10.1002/ps.8628
Haoming Guo, Nan Xiao, Zhixuan Wang, Yabo Liang, Xueke Liu, Peng Wang, Donghui Liu
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BACKGROUNDIndoxacarb, a type of chiral pesticide, is used to control Lepidoptera insects. Most studies had focused on the environmental behavior and selective toxicity of indoxacarb enantiomers, and the mechanism behind its selective biological activity against target organisms is not well understood.RESULTSSpodoptera frugiperda was selected as the target insect. The lethal concentrations (96 h) of indoxacarb enantiomers on S. frugiperda were 2.61 mg/kg (S ‐indoxacarb) and 463.52 mg/kg (R ‐indoxacarb). S ‐Indoxacarb resulted in stronger oxidative damage to S. frugiperda than R ‐indoxacarb, and catalase and malondialdehyde were upregulated by 40.46% and 68.64% respectively after treatment with S ‐indoxacarb. Furthermore, cytochrome P450 and carboxylesterase were activated by S ‐indoxacarb, increasing by 39.62% and 63.68% respectively. Decarbomethoxyllated JW062 (DCJW), a metabolite of indoxacarb, has insecticidal activity. The concentration of DCJW in the S ‐indoxacarb treatment group was 2.73 times that in the R ‐indoxacarb treatment group. Molecular docking results demonstrated that S ‐indoxacarb could spontaneously bind to metabolic enzymes and be metabolized.CONCLUSIONSEnantiomeric bioactivity of indoxacarb enantiomers against on S. frugiperda was observed. S ‐Indoxacarb demonstrated remarkable insecticidal efficacy. Upon ingestion by S. frugiperda , it induced oxidative damage. Furthermore, S ‐indoxacarb was metabolized to DCJW, which has a significant role in its insecticidal properties. The selective bioactivity of indoxacarb enantiomers in S. frugiperda might be attributed to the enantiomeric metabolites. These findings offer a new perspective on the selective mechanisms of chiral pesticides. © 2025 Society of Chemical Industry.
中文翻译:
茚虫威对草地贪夜蛾的立体选择性生物活性及机制
背景杀虫威是一种手性杀虫剂,用于控制鳞翅目昆虫。大多数研究都集中在茚杀威对映异构体的环境行为和选择性毒性上,其对目标生物的选择性生物活性背后的机制尚不清楚。结果选择草地贪夜蛾作为目标昆虫。茚虫威对映异构体对草地贪夜蛙的致死浓度 (96 h) 为 2.61 mg/kg (S-茚杀威) 和 463.52 mg/kg (R-茚杀威)。S-茚杀威对草地贪夜蛾的氧化损伤强于 R-茚杀威,S-茚杀威处理后过氧化氢酶和丙二醛分别上调 40.46% 和 68.64%。此外,S-茚杀威激活细胞色素 P450 和羧酸酯酶,分别增加了 39.62% 和 63.68%。脱碳甲氧基化 JW062 (DCJW) 是茚虫威的代谢产物,具有杀虫活性。S-茚虫威处理组 DCJW 浓度是 R-茚虫威处理组的 2.73 倍。分子对接结果表明,S-茚杀威可以自发地与代谢酶结合并被代谢。结论观察到茚虫威对映异构体对草地链球菌的对抗体活性。S-茚杀威表现出显著的杀虫效果。被 S. frugiperda 摄入后,它诱导了氧化损伤。此外,S-茚虫威被代谢为 DCJW,DCJW 在其杀虫特性中起着重要作用。茚虫威对映异构体在 S. frugiperda 中的选择性生物活性可能归因于对映体代谢物。这些发现为手性农药的选择性机制提供了新的视角。© 2025 化工学会.
更新日期:2025-01-09
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
茚虫威对草地贪夜蛾的立体选择性生物活性及机制
背景杀虫威是一种手性杀虫剂,用于控制鳞翅目昆虫。大多数研究都集中在茚杀威对映异构体的环境行为和选择性毒性上,其对目标生物的选择性生物活性背后的机制尚不清楚。结果选择草地贪夜蛾作为目标昆虫。茚虫威对映异构体对草地贪夜蛙的致死浓度 (96 h) 为 2.61 mg/kg (S-茚杀威) 和 463.52 mg/kg (R-茚杀威)。S-茚杀威对草地贪夜蛾的氧化损伤强于 R-茚杀威,S-茚杀威处理后过氧化氢酶和丙二醛分别上调 40.46% 和 68.64%。此外,S-茚杀威激活细胞色素 P450 和羧酸酯酶,分别增加了 39.62% 和 63.68%。脱碳甲氧基化 JW062 (DCJW) 是茚虫威的代谢产物,具有杀虫活性。S-茚虫威处理组 DCJW 浓度是 R-茚虫威处理组的 2.73 倍。分子对接结果表明,S-茚杀威可以自发地与代谢酶结合并被代谢。结论观察到茚虫威对映异构体对草地链球菌的对抗体活性。S-茚杀威表现出显著的杀虫效果。被 S. frugiperda 摄入后,它诱导了氧化损伤。此外,S-茚虫威被代谢为 DCJW,DCJW 在其杀虫特性中起着重要作用。茚虫威对映异构体在 S. frugiperda 中的选择性生物活性可能归因于对映体代谢物。这些发现为手性农药的选择性机制提供了新的视角。© 2025 化工学会.