The Front Cover shows a transformation pathway leading to the synthesis of key intermediates and the final product, cariprazine, an essential antipsychotic drug, depicting a direct reductive N-alkylation of amines with carboxylic esters in a traditional cooking pot. The vibrant colors and clear structural representations emphasize the efficiency and broad applicability of this one-pot method, which utilizes environmentally friendly reagents, highlighting its potential as a valuable alternative to traditional reductive alkylation method. More information can be found in the Research Article by J. Shen, H. Qin and co-workers (DOI: 10.1002/ejoc.202401285).

中文翻译：

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封面：胺与羧酸酯的直接还原 N-烷基化反应 （Eur. J. Org. Chem. 1/2025）


封面显示了导致关键中间体和最终产品卡利拉嗪（一种必需的抗精神病药物）合成的转化途径，描绘了胺与羧酸酯在传统烹饪锅中的直接还原 N-烷基化反应。鲜艳的色彩和清晰的结构表示强调了这种利用环保试剂的一锅法的效率和广泛适用性，突出了其作为传统还原烷基化方法的宝贵替代方案的潜力。更多信息可以在 J. Shen、H. Qin 及其同事的研究文章 （DOI： 10.1002/ejoc.202401285） 中找到。