The Journal of Nuclear Medicine ( IF 9.1 ) Pub Date : 2025-01-08 , DOI: 10.2967/jnumed.124.268998 Adam L. Kesner, Julia Brosch-Lenz, Jonathan Gear, Michael Lassmann
Dosimetry is integral to informed implementation of radiopharmaceutical therapies, enabling personalized treatment planning and ensuring patient safety by calculating absorbed doses to organs and tumors. As the therapeutic radiopharmaceutical field continues to expand, dosimetry software has emerged as a crucial tool for optimization of treatment efficacy. This review discusses key features and capabilities that current dosimetry software solutions have or should have in the future. We highlight the need for standardization across platforms to support consistent and accurate dose calculations. Furthermore, we explore opportunities for advancing software, such as incorporating biologically effective dose modeling and improving uncertainty quantification. Looking ahead, we advocate for expanding infrastructure for open data sets and fostering ongoing collaboration between vendors and end users to guide the field toward greater integration and efficacy.
中文翻译:
用于治疗诊断应用的剂量测定软件:当前功能和未来前景
剂量测定是放射性药物治疗的知情实施不可或缺的一部分,通过计算器官和肿瘤的吸收剂量,实现个性化的治疗计划并确保患者安全。随着治疗性放射性药物领域的不断扩大,剂量测定软件已成为优化治疗效果的重要工具。本综述讨论了当前剂量学软件解决方案具有或将来应该具有的关键特性和功能。我们强调了跨平台标准化的必要性,以支持一致和准确的剂量计算。此外,我们还探索了改进软件的机会,例如整合生物有效剂量建模和改进不确定性量化。展望未来,我们倡导扩展开放数据集的基础设施,并促进供应商和最终用户之间的持续合作,以指导该领域朝着更大的集成和效率发展。