A new, simple, catalyst‐ and solvent‐free microwave (MW)‐assisted multicomponent method was elaborated for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines. The synthesis was carefully optimized in respect of the molar ratio of the starting materials, the heating mode, the temperature, the reaction time and the effect of different catalysts. The substrate scope of the synthesis was also investigated, and the novel title compounds could be prepared in moderate to good yields. A proposed mechanism for the multicomponent reaction was also provided, in which the iminophosphonate compound could mean a key intermediate through the formation of the desired spiro derivatives.

中文翻译：

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螺氧吲哚二氢吡啶双膦酸盐的微波辅助多组分合成


通过贼丁、β-酮膦酸盐和伯胺的一锅反应，阐述了一种新的、简单的、无催化剂和无溶剂的微波 （MW） 辅助多组分方法，用于合成螺吲哚二氢吡啶双膦酸盐作为一个新的化合物家族。合成在起始材料的摩尔比、加热模式、温度、反应时间和不同催化剂的效果方面进行了仔细优化。还研究了合成的底物范围，可以以中等到良好的产量制备新的标题化合物。还提出了一种多组分反应的机制，其中亚氨基膦酸盐化合物可能意味着通过形成所需的螺衍生物的关键中间体。