Metal- and Light-Free Decarboxylative Giese Addition Reaction Facilitated by Hantzsch Ester,Organic Letters

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Metal- and Light-Free Decarboxylative Giese Addition Reaction Facilitated by Hantzsch Ester
Organic Letters ( IF 4.9 ) Pub Date : 2025-01-07 , DOI: 10.1021/acs.orglett.4c04496
Lei Liang _{1,

2} , Xiao-Shan Deng ₁ , Jing Wang ₁ , Ming Jia ₁ , Xing-Yu Zhu ₁ , Yong Zhang ₁ , Shuai Yuan ₁ , Song-Lin Wang ₁ , Hai-Ming Guo ₂ , Hong-Ying Niu ₁

Affiliation

We have developed a novel strategy for decarboxylative radical addition reactions that employs ground-state reduced nicotinamide adenine dinucleotide (NADH) analogues under ambient and open-air conditions, facilitating the efficient formation of Csp³–Csp³ bonds in a variety of substrates. This protocol is distinguished by its operational simplicity, mild reaction conditions, high efficiency, and the use of cost-effective starting materials. Furthermore, experimental studies have provided valuable insights into the reaction mechanism, elucidating the light-independent pathways that promote these transformations.

中文翻译：

Hantzsch 酯促进的无金属和无光脱羧 Giese 加成反应

我们开发了一种用于脱羧自由基加成反应的新策略，该策略在环境和露天条件下采用基态还原烟酰胺腺嘌呤二核苷酸（NADH）类似物，促进在各种底物中有效形成 Csp^3-Csp ³ 键。该方案的特点是操作简单、反应条件温和、效率高以及使用具有成本效益的起始材料。此外，实验研究为反应机理提供了有价值的见解，阐明了促进这些转变的不依赖光的途径。

更新日期：2025-01-07

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