A stereoselective Ni−Al bimetal‐catalyzed C−H alkenylation of quinazolinones with alkynes has been successfully developed. Good selectivity of Z‐type quinazolinone products was obtained using readily available substrates, which exhibits a trans‐configuration opposite to the conventional alkynylation reactions and improves the diversity of quinazolinone compounds. In addition, the reaction process was further explored through KIE and other control experiments, and a possible mechanism was proposed.

中文翻译：

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Ni-SPO-Al 催化喹唑啉酮与炔烃的立体选择性 C-H 烯基化反应以制备反式异构体


已成功开发了喹唑啉酮与炔烃的立体选择性 Ni-Al 双金属催化的 C-H 烯基化反应。使用现成的底物获得了 Z 型喹唑啉酮产物的良好选择性，其表现出与常规炔基化反应相反的反式构型，并提高了喹唑啉酮化合物的多样性。此外，通过 KIE 和其他对照实验进一步探索了反应过程，并提出了一种可能的机制。