Synthetic methods for monoglycosyl ceramides with various fatty acyl groups were developed, enabling the synthesis of representative brain glycolipids. The immunomodulatory activities of these lipids, depending on their fatty acyl structures, were then examined via CD1d and Mincle. Potent binding of CD1d to endogenous GlcCer with a longer unsaturated fatty acid, such as C24:1, was observed. This binding partially inhibited the interaction with other anti-gens, and it would stabilize the role of CD1d in presenting lipid antigens to NKT cells.

中文翻译：

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脂质结构依赖性 CD1d 功能稳定和内源性葡萄糖神经酰胺的免疫调节


开发了具有各种脂肪酰基的单糖基神经酰胺的合成方法，能够合成具有代表性的脑糖脂。然后通过 CD1d 和 Mincle 检查这些脂质的免疫调节活性，具体取决于它们的脂肪酰基结构。观察到 CD1d 与具有较长不饱和脂肪酸（如 C24：1）的内源性 GlcCer 的有效结合。这种结合部分抑制了与其他抗基因的相互作用，它将稳定 CD1d 在将脂质抗原呈交给 NKT 细胞中的作用。