Advancements in biomedical technologies increasingly demand biocompatible and biodegradable materials capable of integrating with the body for real-time monitoring of physiological processes. Aortic annuloplasty, a procedure to stabilize the aortic root and restore valve function in cases of regurgitation and root dilation, highlights the need for such innovations. Current methods rely on postoperative imaging, which challenges the mapping of the dynamic forces acting on the aortic root and annuloplasty ring during the cardiac cycle. To address this, we assessed the piezoelectric performance of poly-L-lactic acid (PLLA) films, fabricated using solvent casting and processed using uniaxial stretching and thermal annealing, through tapping, straining, and force- and vibration-sweep tests. These tests were conducted to characterize the electrical response of PLLA films under varying mechanical stimuli and evaluate their potential for biomedical sensing. We develop a simple prototype ring-like device to simulate real-world conditions to ascertain its suitability for integration into implantable sensors for continuous, real-time monitoring using a novel in vitro setup for biosignal monitoring of aortic annuloplasty. The device demonstrated stable and periodic voltage outputs correlated with applied pressures, ranging from -0.5 to 0.5 V at 92/51 mmHg to -1.1 to 1.3 V at 164/114 mmHg. These results establish the feasibility of PLLA-based sensors for real-time biomechanical feedback during and after cardiovascular surgeries, paving the way for next-generation monitoring technologies that enhance patient outcomes.

中文翻译：

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利用压电聚左旋乳酸 （PLLA） 增强主动脉瓣环成形术的传感


生物医学技术的进步越来越需要能够与身体整合以实时监测生理过程的生物相容性和可生物降解材料。主动脉瓣环成形术是一种在反流和牙根扩张的情况下稳定主动脉根部并恢复瓣膜功能的手术，突出了此类创新的必要性。目前的方法依赖于术后成像，这挑战了心动周期期间作用在主动脉根部和瓣环成形术环上的动态力的映射。为了解决这个问题，我们通过敲击、应变以及力和振动扫描测试评估了聚左旋乳酸 （PLLA） 薄膜的压电性能，该薄膜使用溶剂铸造制造并使用单轴拉伸和热退火加工。进行这些测试是为了表征 PLLA 薄膜在不同机械刺激下的电响应并评估它们在生物医学传感方面的潜力。我们开发了一种简单的原型环状设备来模拟真实世界的条件，以确定其是否适合集成到植入式传感器中，以便使用用于主动脉瓣环成形术生物信号监测的新型体外装置进行连续、实时监测。该器件表现出与施加的压力相关的稳定和周期性电压输出，范围从 92/51 mmHg 的 -0.5 至 0.5 V 到 164/114 mmHg 的 -1.1 至 1.3 V。这些结果确定了基于 PLLA 的传感器在心血管手术期间和之后进行实时生物力学反馈的可行性，为提高患者预后的下一代监测技术铺平了道路。