Accumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metabolic homeostasis related to bone health. This review provides a comprehensive analysis of how skeletal interoception influences bone homeostasis, delving into the complex interplay between the nervous system and skeletal system. One key focus of the review is the role of various factors such as prostaglandin E2 (PGE2) in skeletal health via skeletal interoception. It explores how nerves innervating the bone tissue communicate with the central nervous system to regulate bone remodeling, a process critical for maintaining bone strength and integrity. Additionally, the review highlights the advancements in biomaterials designed to utilize skeletal interoception for enhancing bone regeneration and treatment of bone disorders. These biomaterials, tailored to interact with the body’s interoceptive pathways, are positioned at the forefront of innovative treatments for conditions like osteoporosis and fractures. They represent a convergence of bioengineering, neuroscience, and orthopedics, aiming to create more efficient and targeted therapies for bone-related disorders. In conclusion, the review underscores the importance of skeletal interoception in physiological regulation and its potential in developing more effective therapies for bone regeneration. It emphasizes the need for further research to fully understand the mechanisms of skeletal interoception and to harness its therapeutic potential fully.

不断积累的研究揭示了骨骼内感受在维持与骨骼健康相关的生理和代谢稳态方面的重要性。这篇综述全面分析了骨骼内感受如何影响骨稳态，深入研究了神经系统和骨骼系统之间复杂的相互作用。本综述的一个重点是各种因素，如前列腺素 E2 （PGE2） 通过骨骼内感受在骨骼健康中的作用。它探讨了支配骨组织的神经如何与中枢神经系统交流以调节骨骼重塑，这是维持骨骼强度和完整性的关键过程。此外，该综述强调了旨在利用骨骼内感受增强骨骼再生和治疗骨骼疾病的生物材料的进步。这些生物材料专为与人体的内感受通路相互作用而量身定制，处于骨质疏松症和骨折等疾病创新疗法的最前沿。它们代表了生物工程、神经科学和骨科的融合，旨在为骨骼相关疾病创造更有效和有针对性的疗法。总之，该综述强调了骨骼内感受在生理调节中的重要性及其在开发更有效的骨再生疗法方面的潜力。它强调需要进一步研究以充分了解骨骼内感受的机制并充分利用其治疗潜力。