Asymmetric alkynylation of seven-membered cyclic imine dibenzo[b,f][1,4]oxazepines is successfully achieved by combining chiral phosphoric acid and Ag(I) catalysts. Various arylacetylenes, conjugated enynes, and terminal 1,3-diynes are good substrates for this reaction, and aliphatic hexyne is also a suitable donor at elevated temperature. Optimization of this approach has provided a facile method to synthesize optically active 11-substituted-10,11-dihydrodibenzo[b,f][1,4]oxazepine derivatives containing a carbon–carbon triple bond with 63–99% ee. Subsequent transformations of the carbon–carbon triple bond for the heterocyclic products have been disclosed.

中文翻译：

---

手性磷酸和Ag（I）催化剂结合组成的七元环亚胺的不对称炔基化反应：合成11-取代的10,11-二氢二苯并[ b，f ] [1,4]氧杂氮平衍生物

通过结合手性磷酸和Ag（I）催化剂成功地实现了七元环亚胺二苯并[ b，f ] [1,4]氧杂氮杂烷的不对称炔基化反应。各种芳基乙炔，共轭烯炔和末端1,3-二炔是该反应的良好底物，脂族己炔在高温下也是合适的供体。这种方法的优化提供了一种简便的方法，可以合成具有63-99％ee的碳-碳三键的光学活性11-取代的10,11-二氢二苯并[ b，f ] [1,4]奥氮平衍生物。已公开了杂环产物的碳-碳三键的后续转变。