Efficient glycosylation methods are continuously being developed to obtain homogeneously pure carbohydrates to study their biological roles. The development of effective and stereoselective glycosylations using novel anomeric leaving groups constitutes an active area of research in synthetic carbohydrate chemistry. Although various glycosyl donors have been developed over the decades, anomeric esters as donors in glycosylation have received significant attention in recent times due to their convenience of preparation, shelf stability, catalytic activation, mild conditions, and high glycosylation efficiency. We focus in this mini‐review on covering the glycosyl ester‐containing donors utilized in chemical glycosylation methods, including simple esters, alkenyl, alkynyl‐containing esters, carbonate esters, chelation‐assisted glycosyl esters, allenyl and ynenoate glycosyl esters in glycoside synthesis.

中文翻译：

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糖基酯作为化学糖基化中的稳定供体


高效的糖基化方法正在不断开发，以获得均一纯的碳水化合物，以研究它们的生物学作用。使用新型异头离去基团开发有效的立体选择性糖基化构成了合成碳水化合物化学的一个活跃研究领域。尽管几十年来已经开发了各种糖基供体，但作为糖基化供体的异头酯由于其制备方便、货架稳定性、催化活化、条件温和和高糖基化效率而近年来受到了极大的关注。在本小型综述中，我们重点介绍了化学糖基化方法中使用的含糖基酯的供体，包括简单酯、烯基、含炔基的酯、碳酸盐酯、螯合辅助糖基酯、糖苷合成中的烯丙基和炔酸酯。