Sulfonamide antibiotics have a broad spectrum of antibacterial action and are widely used, but their overuse poses a threat to human health. In this study, a three-dimensional conjugated microporous polymer, which was designated as TPM-CMP, was synthesized via Friedel-Crafts reaction by using tetraphenylmethane (TPM) and biphenyl dichlorobenzene as monomers, and it was utilized as an adsorbent in solid-phase extraction (SPE) of sulfonamides. The TPM-CMP demonstrated high extraction efficiency for sulfonamides due to π-stacking interactions, hydrophobic forces, and pore-filling effects. Consequently, the SPE was combined with liquid chromatography to detect sulfonamides in milk samples. For this method established in this study, a good linear response was observed in the range of 3.3–300.0 ng g⁻¹, with a detection limit (S/N = 3) between 1.0 and 1.5 ng g⁻¹. The method recoveries of four sulfonamide in milk samples ranged from 83.4 % to 117 %, with relative standard deviations below 10 %.

中文翻译：

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基于四苯甲烷的三维共轭微孔聚合物作为固相萃取牛奶样品中痕量磺酰胺类抗生素的吸附剂


磺胺类抗生素具有广泛的抗菌作用并被广泛使用，但其过度使用对人类健康构成威胁。本研究以四苯甲烷 （TPM） 和联苯二氯苯为单体，通过 Friedel-Crafts 反应合成了一种三维共轭微孔聚合物，命名为 TPM-CMP，并用作磺胺类药物固相萃取 （SPE） 的吸附剂。由于π堆积相互作用、疏水力和孔隙填充效应，TPM-CMP 表现出对磺胺类药物的高提取效率。因此，将 SPE 与液相色谱相结合，以检测牛奶样品中的磺胺类药物。对于本研究中建立的这种方法，在 3.3–300.0 ng ^g-1 范围内观察到良好的线性响应，检测限 （S/N = 3） 在 1.0 和 1.5 ng ^g-1 之间。牛奶样品中四种磺胺类药物的方法回收率范围为 83.4 % 至 117 %，相对标准偏差低于 10 %。